Meister Marie
Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg, France.
Curr Opin Immunol. 2004 Feb;16(1):10-5. doi: 10.1016/j.coi.2003.11.002.
Drosophila haemopoiesis gives rise to three independent cell lineages: plasmatocytes, crystal cells and lamellocytes. The regulation of Drosophila stem cell proliferation and lineage specification involves transactivators and signalling pathways, many of which have mammalian counterparts that control haemopoietic processes. Drosophila plasmatocytes are professional phagocytes that resemble the monocyte/macrophage lineage, crystal cells play a critical role in defence-related melanisation, and lamellocytes encapsulate large invaders. Crystal cells and lamellocytes have no clear mammalian homologues. Research into the molecular mechanisms that underlie the various immune functions of Drosophila blood cells, such as non-self recognition, is now taking wing.
浆血细胞、晶细胞和片层细胞。果蝇干细胞增殖和谱系特化的调控涉及转录激活因子和信号通路，其中许多在哺乳动物中具有控制造血过程的对应物。果蝇浆血细胞是专业吞噬细胞，类似于单核细胞/巨噬细胞谱系；晶细胞在与防御相关的黑化过程中起关键作用；片层细胞则包裹大型入侵者。晶细胞和片层细胞在哺乳动物中没有明确的同源物。对果蝇血细胞各种免疫功能（如非自我识别）背后分子机制的研究目前正在兴起。
