Sugiyama K, Ueda H, Ichio Y, Yokota M
Institute of Traditional Chinese Medicines, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Biol Pharm Bull. 1995 Jan;18(1):53-8. doi: 10.1248/bpb.18.53.
The effects of oral treatment with 1-, 5-, 10- and 20-fold the usual daily dose of Juzen-taiho-to on the nephrotoxicity, immunosuppression, hepatic toxicity and gastrointestinal toxicity caused by i.p. administration of 3.0 mg/kg cisplatin (CDDP) 9 times (on days 3, 4, 5, 6, 7, 8, 10, 11, and 12) were examined in ddY mice inoculated with sarcoma 180 (S-180) cells on day 1. The increase in blood urea nitrogen, serum creatinine, serum glutamic-oxaloacetic transaminase, serum glutamic-pyruvic transaminases and relative stomach weight and decrease in white blood cell count, platelet count, relative spleen and thymus weight, food intake and body weight caused by CDDP were inhibited to nearly the control levels without reducing the antitumor activity of CDDP against S-180 by the oral treatment with either 10-fold (1.7 g/kg) or 20-fold (3.4 g/kg) the usual daily dose of Juzen-taiho-to 12 times (on days 3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14, and 15). All the mice receiving 4.5, 6.0, 7.5, 9.0, and 12.0 mg/kg CDDP died by day 12, while treatment with 3.4 g/kg Juzen-taiho-to efficiently prolonged the survival time. These findings indicate that Juzen-taiho-to may provide protection against most clinical toxicity caused by CDDP, and Juzen-taiho-to may allow us to administer a much higher dose of CDDP in clinical therapy.
在第1天接种肉瘤180（S-180）细胞的ddY小鼠中，研究了口服1倍、5倍、10倍和20倍常规日剂量的十全大补汤对腹腔注射3.0mg/kg顺铂（CDDP）9次（第3、4、5、6、7、8、10、11和12天）所引起的肾毒性、免疫抑制、肝毒性和胃肠道毒性的影响。顺铂导致的血尿素氮、血清肌酐、血清谷草转氨酶、血清谷丙转氨酶升高以及相对胃重量增加，以及白细胞计数、血小板计数、相对脾脏和胸腺重量、食物摄入量和体重下降，通过口服10倍（1.7g/kg）或20倍（3.4g/kg）常规日剂量的十全大补汤12次（第3、4、5、6、7、8、10、11、12、13、14和15天）被抑制至接近对照水平，而未降低顺铂对S-180的抗肿瘤活性。所有接受4.5、6.0、7.5、9.0和12.0mg/kg顺铂的小鼠在第12天死亡，而用3.4g/kg十全大补汤治疗有效地延长了存活时间。这些发现表明，十全大补汤可能对顺铂引起的大多数临床毒性提供保护作用，并且十全大补汤可能使我们在临床治疗中能够给予更高剂量的顺铂。
