Löffler Dirk, Ternes Thomas A
Bundesanstalt für Gewässerkunde, P.O. Box 20 02 53, D-56002 Koblenz, Germany.
J Chromatogr A. 2003 Dec 22;1021(1-2):133-44. doi: 10.1016/j.chroma.2003.08.089.
Analytical methods have been developed for the determination of eight acidic pharmaceuticals and two metabolites, seven antibiotics and the parasiticide ivermectin in a selected river sediment. The sediments were solvent extracted with ultrasonic assistance. A solid phase extraction (SPE) clean-up step was performed thereafter. The acidic compounds clofibric acid, diclofenac, fenoprofen, gemfibrozil, ibuprofen, 2-hydroxy-ibuprofen, indomethacin, ketoprofen, naproxen and the parasiticide ivermectin were measured in the negative mode by LC-APCI-tandem MS, whereas the antibiotics clarithromycin, erythromycin, roxithromycin, sulfadiazine, sulfamethazine, sulfamethoxazole and trimethoprim were detected in the positive mode by LC-ESI-tandem MS. Bezafibrate could not be determined in the sediment using the method developed. The limit of quantification (LOQ) ranged from 0.4 to 8 ng g(-1) for the acidic pharmaceuticals, sulfadiazine and ivermectin and was 20 ng g(-1) for the other antibiotics.
已开发出分析方法，用于测定某选定河流沉积物中的8种酸性药物及2种代谢物、7种抗生素和杀寄生虫剂伊维菌素。沉积物经超声辅助溶剂萃取，随后进行固相萃取（SPE）净化步骤。酸性化合物氯贝酸、双氯芬酸、非诺洛芬、吉非罗齐、布洛芬、2-羟基布洛芬、吲哚美辛、酮洛芬、萘普生和杀寄生虫剂伊维菌素通过LC-APCI串联质谱在负离子模式下测定，而抗生素克拉霉素、红霉素、罗红霉素、磺胺嘧啶、磺胺二甲嘧啶、磺胺甲恶唑和甲氧苄啶则通过LC-ESI串联质谱在正离子模式下检测。使用所开发的方法无法测定沉积物中的苯扎贝特。酸性药物、磺胺嘧啶和伊维菌素的定量限（LOQ）为0.4至8 ng g⁻¹，其他抗生素的定量限为20 ng g⁻¹。
