格利索普伦菌素，由 Gliocladium sp. FO - 1513 产生的新型酰基辅酶 A：胆固醇酰基转移酶抑制剂。II. 格利索普伦菌素 A 和 B 的结构解析。
Glisoprenins, new inhibitors of acyl-CoA: cholesterol acyltransferase produced by Gliocladium sp. FO-1513. II. Structure elucidation of glisoprenins A and B.
作者信息
Nishida H, Huang X H, Tomoda H, Omura S
机构信息
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1992 Oct;45(10):1669-76. doi: 10.7164/antibiotics.45.1669.
PMID:1473995
Abstract
The structure of glisoprenins A and B, novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors, was determined by spectroscopic analyses, mainly 1H and 13C NMR and MS. Glisoprenin A was deduced to be a tetrahydroxynonaprenol and glisoprenin B to be an oxidative modification of glisoprenin A.
摘要
新型酰基辅酶A：胆固醇酰基转移酶（ACAT）抑制剂格利索普瑞宁A和B的结构通过光谱分析确定，主要是1H和13C核磁共振以及质谱分析。推断格利索普瑞宁A为四羟基壬烯醇，格利索普瑞宁B是格利索普瑞宁A的氧化修饰产物。
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