fexA，一个编码对氟苯尼考和氯霉素耐药性的缓慢葡萄球菌新基因。
fexA, a novel Staphylococcus lentus gene encoding resistance to florfenicol and chloramphenicol.
作者信息
Kehrenberg Corinna, Schwarz Stefan
机构信息
Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft, 31535 Neustadt-Mariensee, Germany.
出版信息
Antimicrob Agents Chemother. 2004 Feb;48(2):615-8. doi: 10.1128/AAC.48.2.615-618.2004.
Abstract
The Staphylococcus lentus plasmid pSCFS2 carries a novel florfenicol-chloramphenicol resistance gene, designated fexA, encoding a protein of 475 amino acids with 14 transmembrane domains. The FexA protein differs from all previously known proteins involved in the efflux of chloramphenicol and florfenicol. Induction of fexA expression by chloramphenicol and florfenicol occurs via translational attenuation.
摘要
迟缓葡萄球菌质粒pSCFS2携带一个新的氟苯尼考-氯霉素抗性基因，命名为fexA，其编码一个含有14个跨膜结构域的475个氨基酸的蛋白质。FexA蛋白与所有先前已知的参与氯霉素和氟苯尼考外排的蛋白质不同。氯霉素和氟苯尼考通过翻译弱化诱导fexA表达。
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本文引用的文献
1
Staphylococcus sciuri gene erm(33), encoding inducible resistance to macrolides, lincosamides, and streptogramin B antibiotics, is a product of recombination between erm(C) and erm(A).
Antimicrob Agents Chemother. 2002 Nov;46(11):3621-3. doi: 10.1128/AAC.46.11.3621-3623.2002.
2
Antimicrobial resistance in staphylococci from animals with particular reference to bovine Staphylococcus aureus, porcine Staphylococcus hyicus, and canine Staphylococcus intermedius.
Vet Res. 2001 May-Aug;32(3-4):341-62. doi: 10.1051/vetres:2001129.
3
Use of antimicrobials in veterinary medicine and mechanisms of resistance.
Vet Res. 2001 May-Aug;32(3-4):201-25. doi: 10.1051/vetres:2001120.
4
Whole genome sequencing of meticillin-resistant Staphylococcus aureus.
Lancet. 2001 Apr 21;357(9264):1225-40. doi: 10.1016/s0140-6736(00)04403-2.
5
Identification of a plasmid-borne chloramphenicol-florfenicol resistance gene in Staphylococcus sciuri.
Antimicrob Agents Chemother. 2000 Sep;44(9):2530-3. doi: 10.1128/AAC.44.9.2530-2533.2000.
6
Proton-dependent multidrug efflux systems.
Microbiol Rev. 1996 Dec;60(4):575-608. doi: 10.1128/mr.60.4.575-608.1996.
7
O-Acetyltransferases for chloramphenicol and other natural products.
Antimicrob Agents Chemother. 1997 Jan;41(1):1-6. doi: 10.1128/AAC.41.1.1.
8
Nucleotide sequence and functional map of pC194, a plasmid that specifies inducible chloramphenicol resistance.
J Bacteriol. 1982 May;150(2):815-25. doi: 10.1128/jb.150.2.815-825.1982.
9
Improved estimation of secondary structure in ribonucleic acids.
Nat New Biol. 1973 Nov 14;246(150):40-1. doi: 10.1038/newbio246040a0.
10
Antimicrobial resistance of Staphylococcus aureus: genetic basis.
Microbiol Rev. 1987 Mar;51(1):88-134. doi: 10.1128/mr.51.1.88-134.1987.
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