Waldum H L, Mignon M, Sandvik A K, Bonfils S
Dept. of Medicine, University Hospital, Trondheim, Norway.
Scand J Gastroenterol. 1992 Dec;27(12):1039-44. doi: 10.3109/00365529209028135.
The biologic gastrin activity in serum from 14 patients with the Zollinger-Ellison syndrome was assessed by the stimulation of histamine release and acid secretion from the isolated vascularly perfused rat stomach and compared with the immunologic activity as determined by radioimmunoassay using an antibody directed towards the active site of the gastrin molecule. Biologic gastrin activity assessed by the stimulation of histamine release was more closely correlated to immunologic gastrin activity than biologic activity assessed by the stimulation of gastrin acid secretion. This study does not contradict the concept that gastrin stimulates acid secretion at least partly by releasing histamine and also shows that the immunologic gastrin activity determined with the help of an antibody directed towards the active site reflects biologic activity.
通过刺激从离体血管灌注大鼠胃中释放组胺和胃酸分泌，对14例佐林格 - 埃利森综合征患者血清中的生物胃泌素活性进行了评估，并与使用针对胃泌素分子活性位点的抗体通过放射免疫测定法测定的免疫活性进行了比较。通过刺激组胺释放评估的生物胃泌素活性比通过刺激胃酸分泌评估的生物活性与免疫胃泌素活性的相关性更强。本研究并不与胃泌素至少部分通过释放组胺来刺激胃酸分泌这一概念相矛盾，并且还表明借助针对活性位点的抗体测定的免疫胃泌素活性反映了生物活性。
