• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

南非西开普省农村地区耐药结核分枝杆菌分离株的基因型和表型特征

Genotypic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates from rural districts of the Western Cape Province of South Africa.

作者信息

Streicher E M, Warren R M, Kewley C, Simpson J, Rastogi N, Sola C, van der Spuy G D, van Helden P D, Victor T C

机构信息

MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, Tygerberg, South Africa.

出版信息

J Clin Microbiol. 2004 Feb;42(2):891-4. doi: 10.1128/JCM.42.2.891-894.2004.

DOI:10.1128/JCM.42.2.891-894.2004
PMID:14766882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC344460/
Abstract

Genotypic and phenotypic analysis of drug-resistant Mycobacterium tuberculosis isolates from the Western Cape Province of South Africa showed that drug resistance is widespread and recently transmitted. Multidrug-resistant (MDR) isolates comprise 40% of this collection, and a large pool of isoniazid monoresistance may be a future source of MDR tuberculosis.

摘要

对来自南非西开普省的耐药结核分枝杆菌分离株进行的基因型和表型分析表明，耐药情况广泛且为近期传播。耐多药（MDR）分离株占该样本的40%，大量的异烟肼单耐药株可能是未来耐多药结核病的一个来源。

相似文献

1
Genotypic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates from rural districts of the Western Cape Province of South Africa.南非西开普省农村地区耐药结核分枝杆菌分离株的基因型和表型特征
J Clin Microbiol. 2004 Feb;42(2):891-4. doi: 10.1128/JCM.42.2.891-894.2004.
2
Ethambutol resistance testing by mutation detection.通过突变检测进行乙胺丁醇耐药性检测。
Int J Tuberc Lung Dis. 2006 Jan;10(1):68-73.
3
Rapid genotypic assays to identify drug-resistant Mycobacterium tuberculosis in South Africa.用于鉴定南非耐多药结核分枝杆菌的快速基因分型检测方法。
J Antimicrob Chemother. 2009 Jan;63(1):11-6. doi: 10.1093/jac/dkn433. Epub 2008 Oct 21.
4
Clonality and genetic profiles of drug-resistant Mycobacterium tuberculosis in the Eastern Cape Province, South Africa.南非东开普省耐药结核分枝杆菌的克隆性和遗传特征。
Microbiologyopen. 2019 Mar;8(3):e00449. doi: 10.1002/mbo3.449. Epub 2019 Feb 23.
5
Genetic diversity of Mycobacterium tuberculosis isoniazid monoresistant and multidrug-resistant in Rio Grande do Sul, a tuberculosis high-burden state in Brazil.巴西南部结核病高负担州南里奥格兰德州结核分枝杆菌异烟肼单耐药和多耐药的基因多样性。
Tuberculosis (Edinb). 2018 May;110:36-43. doi: 10.1016/j.tube.2018.02.009. Epub 2018 Mar 1.
6
Multi- and Extensively Drug Resistant Mycobacterium tuberculosis in South Africa: a Molecular Analysis of Historical Isolates.南非的耐多药和广泛耐药结核分枝杆菌：历史分离株的分子分析。
J Clin Microbiol. 2018 Apr 25;56(5). doi: 10.1128/JCM.01214-17. Print 2018 May.
7
Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape Province of South Africa.在北京和哈勒姆基因型在南非西开普省耐多药结核病儿童中所占比例过高。
J Clin Microbiol. 2006 Oct;44(10):3539-43. doi: 10.1128/JCM.01291-06. Epub 2006 Aug 23.
8
Prevalence of isoniazid resistance-conferring mutations associated with multidrug-resistant tuberculosis in Free State Province, South Africa.南非自由州省与耐多药结核病相关的异烟肼耐药突变体的流行情况。
S Afr Med J. 2019 Aug 28;109(9):659-664. doi: 10.7196/SAMJ.2019.v109i9.13730.
9
Characterization of phenotypic and genotypic drug resistance patterns of Mycobacterium tuberculosis isolates from a city in Mexico.对来自墨西哥一个城市的结核分枝杆菌分离株的表型和基因型耐药模式的特征分析。
Enferm Infecc Microbiol Clin. 2015 Mar;33(3):181-5. doi: 10.1016/j.eimc.2014.04.005. Epub 2014 Jun 18.
10
Phenotypic and genotypic analysis of anti-tuberculosis drug resistance in Mycobacterium tuberculosis isolates in Myanmar.缅甸结核分枝杆菌分离株中抗结核药物耐药性的表型和基因型分析。
Ann Lab Med. 2015 Sep;35(5):494-9. doi: 10.3343/alm.2015.35.5.494.

引用本文的文献

1
Resistance to pyrazinamide in complex isolates from previously treated tuberculosis cases in Southwestern Oromia, Ethiopia.埃塞俄比亚奥罗米亚西南部既往治疗过的结核病病例中复杂分离株对吡嗪酰胺的耐药性
J Clin Tuberc Other Mycobact Dis. 2023 Dec 25;34:100411. doi: 10.1016/j.jctube.2023.100411. eCollection 2024 Feb.
2
Transmission in High-Incidence Settings-New Paradigms and Insights.高发病率环境中的传播——新范式与见解
Pathogens. 2022 Oct 25;11(11):1228. doi: 10.3390/pathogens11111228.
3
Molecular epidemiology of drug resistant Mycobacterium tuberculosis in Africa: a systematic review.非洲耐药结核分枝杆菌的分子流行病学：系统评价。
BMC Infect Dis. 2020 May 13;20(1):344. doi: 10.1186/s12879-020-05031-5.
4
Clonality and genetic profiles of drug-resistant Mycobacterium tuberculosis in the Eastern Cape Province, South Africa.南非东开普省耐药结核分枝杆菌的克隆性和遗传特征。
Microbiologyopen. 2019 Mar;8(3):e00449. doi: 10.1002/mbo3.449. Epub 2019 Feb 23.
5
Methods used in the spatial analysis of tuberculosis epidemiology: a systematic review.结核病流行病学空间分析方法：系统评价。
BMC Med. 2018 Oct 18;16(1):193. doi: 10.1186/s12916-018-1178-4.
6
Geospatial distribution of Mycobacterium tuberculosis genotypes in Africa.非洲结核分枝杆菌基因型的地理空间分布。
PLoS One. 2018 Aug 1;13(8):e0200632. doi: 10.1371/journal.pone.0200632. eCollection 2018.
7
Diversity of Complex from Cattle Lymph Nodes in Eastern Cape Province.东开普省牛淋巴结中复杂病原体的多样性。
Biomed Res Int. 2018 Apr 10;2018:3683801. doi: 10.1155/2018/3683801. eCollection 2018.
8
Biology of clinical strains of Mycobacterium tuberculosis with varying levels of transmission.具有不同传播水平的结核分枝杆菌临床菌株的生物学特性
Tuberculosis (Edinb). 2018 Mar;109:123-133. doi: 10.1016/j.tube.2018.02.003. Epub 2018 Feb 9.
9
SMRT genome assembly corrects reference errors, resolving the genetic basis of virulence in Mycobacterium tuberculosis.单分子实时（SMRT）基因组组装纠正了参考错误，解析了结核分枝杆菌毒力的遗传基础。
BMC Genomics. 2017 Apr 17;18(1):302. doi: 10.1186/s12864-017-3687-5.
10
Diverse Molecular Genotypes of Mycobacterium tuberculosis Complex Isolates Circulating in the Free State, South Africa.在南非自由邦流通的结核分枝杆菌复合群分离株的多种分子基因型
Int J Microbiol. 2016;2016:6572165. doi: 10.1155/2016/6572165. Epub 2016 Mar 17.

本文引用的文献

1
Snapshot of moving and expanding clones of Mycobacterium tuberculosis and their global distribution assessed by spoligotyping in an international study.在一项国际研究中，通过间隔寡核苷酸分型技术评估结核分枝杆菌移动和扩展克隆的概况及其全球分布。
J Clin Microbiol. 2003 May;41(5):1963-70. doi: 10.1128/JCM.41.5.1963-1970.2003.
2
Historic and recent events contribute to the disease dynamics of Beijing-like Mycobacterium tuberculosis isolates in a high incidence region.历史事件和近期事件影响了高发病率地区北京基因型结核分枝杆菌菌株的疾病动态。
Int J Tuberc Lung Dis. 2002 Nov;6(11):1001-11.
3
Global distribution of Mycobacterium tuberculosis spoligotypes.结核分枝杆菌间隔寡核苷酸分型的全球分布
Emerg Infect Dis. 2002 Nov;8(11):1347-9. doi: 10.3201/eid0811.020125.
4
Worldwide occurrence of Beijing/W strains of Mycobacterium tuberculosis: a systematic review.结核分枝杆菌北京/W菌株在全球的出现：一项系统综述。
Emerg Infect Dis. 2002 Aug;8(8):843-9. doi: 10.3201/eid0805.020002.
5
Molecular characterization of multiple-drug-resistant Mycobacterium tuberculosis isolates from northwestern Russia and analysis of rifampin resistance using RNA/RNA mismatch analysis as compared to the line probe assay and sequencing of the rpoB gene.俄罗斯西北部耐多药结核分枝杆菌分离株的分子特征分析以及与线性探针分析和rpoB基因测序相比，使用RNA/RNA错配分析对利福平耐药性的分析。
Res Microbiol. 2002 May;153(4):213-9. doi: 10.1016/s0923-2508(02)01311-6.
6
A data-mining approach to spacer oligonucleotide typing of Mycobacterium tuberculosis.一种用于结核分枝杆菌间隔区寡核苷酸分型的数据挖掘方法。
Bioinformatics. 2002 Feb;18(2):235-43. doi: 10.1093/bioinformatics/18.2.235.
7
Global dissemination of the Mycobacterium tuberculosis W-Beijing family strains.结核分枝杆菌W-北京家族菌株的全球传播。
Trends Microbiol. 2002 Jan;10(1):45-52. doi: 10.1016/s0966-842x(01)02277-6.
8
Spoligotype database of Mycobacterium tuberculosis: biogeographic distribution of shared types and epidemiologic and phylogenetic perspectives.结核分枝杆菌的寡核苷酸分型数据库：共享型的生物地理分布以及流行病学和系统发育学视角
Emerg Infect Dis. 2001 May-Jun;7(3):390-6. doi: 10.3201/eid0703.010304.
9
Classification of drug-resistant tuberculosis in an epidemic area.某流行地区耐药结核病的分类
Lancet. 2000 Jul 1;356(9223):22-5. doi: 10.1016/S0140-6736(00)02429-6.
10
Transmission of a multidrug-resistant Mycobacterium tuberculosis strain resembling "strain W" among noninstitutionalized, human immunodeficiency virus-seronegative patients.一种类似于“W菌株”的耐多药结核分枝杆菌菌株在非住院、人类免疫缺陷病毒血清学阴性患者中的传播。
J Infect Dis. 1999 Nov;180(5):1608-15. doi: 10.1086/315054.