Ohkoshi K, Tsiaras W G
Department of Ophthalmology, Brown University.
Br J Ophthalmol. 1992 Nov;76(11):651-5. doi: 10.1136/bjo.76.11.651.
In order to assess the systemic prognosis of children with leukaemic ocular involvement, 63 of 131 patients admitted to hospital with acute leukaemia were evaluated ophthalmically. A total of 28 of 63 showed ophthalmic involvement and were followed up for up to 84 months. Twenty seven of 28 patients (96.4%) died within 28 months after the onset of ocular involvement and within 83 months after the onset of leukaemia. The 5 year survival rate of patients with ophthalmic manifestations was 21.4% (6/28). This survival rate was significantly lower than that of those who lacked ophthalmic manifestations (16/35: 45.7%, p < 0.05). All of the patients with ophthalmic manifestations had either bone marrow relapse or central nervous system leukaemia. The prognosis was related to risk factors such as central nervous system leukaemia or bone marrow relapse in most cases.
为评估白血病眼部受累患儿的全身预后，对131例因急性白血病入院的患者中的63例进行了眼科评估。63例中共有28例出现眼部受累，并进行了长达84个月的随访。28例患者中有27例（96.4%）在眼部受累发病后28个月内及白血病发病后83个月内死亡。有眼部表现的患者5年生存率为21.4%（6/28）。该生存率显著低于无眼部表现的患者（16/35：45.7%，p<0.05）。所有有眼部表现的患者均发生了骨髓复发或中枢神经系统白血病。在大多数情况下，预后与中枢神经系统白血病或骨髓复发等危险因素有关。
