Baron T H, Richter J E
Division of Gastroenterology, University of Alabama, Birmingham.
Gastroenterol Clin North Am. 1992 Dec;21(4):777-91.
Heartburn during pregnancy occurs in approximately two thirds of all pregnancies. The origin is multifactorial, but the predominant factor is a decrease in LES pressure resulting from female sex hormones, especially progesterone. Mechanical factors play a small role. Serious reflux complications during pregnancy are rare outside the obstetric setting. Therapy involves lifestyle modifications and nonsystemic medications as the initial choices. H2 blockers are probably safe in severe and refractory cases.
孕期胃灼热在所有妊娠中约三分之二会出现。其病因是多因素的，但主要因素是女性性激素，尤其是孕酮导致的食管下括约肌压力降低。机械因素起的作用较小。在产科环境之外，孕期严重的反流并发症很少见。治疗首先包括生活方式调整和非系统性药物。在严重和难治性病例中，H2受体阻滞剂可能是安全的。
