Bermúdez M V, Martinez F J, Salazar M E, Waksman N, Piñeyro A
Facultad de Medicina, Universidad Autónoma de Nuevo León, Col del Valle, México.
Toxicon. 1992 Nov;30(11):1493-6. doi: 10.1016/0041-0101(92)90527-c.
Previous acute toxicity studies with 'Tullidora' in mice showed mainly hepatic and pulmonary complications. We tested samples in rat, guinea-pig, hamster and dog, searching for the mechanism of death. A single oral preparation of ripe fruit of Karwinskia humboldtiana was given to all animals. Clinical signs and histopathology were reproduced in all species except dogs. We propose a selective toxicity of the toxins of this fruit to the lungs and liver.
之前对小鼠进行的“图利多拉”急性毒性研究主要显示出肝脏和肺部并发症。我们在大鼠、豚鼠、仓鼠和狗身上测试了样本，以探寻死亡机制。给所有动物单次口服洪堡卡罗琳斯卡果的成熟果实制剂。除狗之外，所有物种均再现了临床症状和组织病理学变化。我们提出这种果实的毒素对肺和肝脏具有选择性毒性。
