Win K, Than M, Thwe Y
Malaria Research Programme, Ministry of Defence, Yangon, Myanmar.
Bull World Health Organ. 1992;70(6):777-82.
A total of 141 cases of strictly defined cerebral malaria were studied in a controlled trial of three regimens: (1) intramuscular artemether plus oral mefloquine, (2) intravenous artesunate plus oral mefloquine, and (3) intravenous quinine (with or without an initial loading dose) plus oral tetracycline. The overall mortalities in each group were 14%, 8.3% and 34.3% respectively. The average parasite clearance time was 27.30 +/- 19.62 hours in regimen 1, 41.84 +/- 17.55 hours in regimen 2, and 47.30 +/- 21.95 hours in regimen 3. No recrudescence was observed in regimens 1 and 2, but 12.1% recrudesced in the third.
在一项针对三种治疗方案的对照试验中,共研究了141例严格定义的脑型疟病例:(1)肌肉注射蒿甲醚加口服甲氟喹;(2)静脉注射青蒿琥酯加口服甲氟喹;(3)静脉注射奎宁(有或无初始负荷剂量)加口服四环素。每组的总死亡率分别为14%、8.3%和34.3%。方案1的平均疟原虫清除时间为27.30±19.62小时,方案2为41.84±17.55小时,方案3为47.30±21.95小时。方案1和2未观察到复发,但方案3中有12.1%出现复发。