Clandinin M T, Parrott A, Van Aerde J E, Hervada A R, Lien E
Nutrition and Metabolism Research Group, University of Alberta, Edmonton, Canada.
Early Hum Dev. 1992 Nov;31(1):41-51. doi: 10.1016/0378-3782(92)90013-7.
Thirty-four premature infants weighing less than 1500 grams at birth were fed preterm formula (formula), preterm infant formula manufactured to contain a balance of C20 and C22 omega 6 and omega 3 fatty acids within the range characteristic of human milk (LCPE-formula) or their mothers' expressed breast milk (EBM). Blood samples were obtained during the first week of life and after 28 days of feeding to determine the effect of feeding C20 and C22 omega 6 and omega 3 fatty acids on plasma lipids. Fatty acid analyses of red blood cell phospholipids indicated few differences between dietary treatment and age. Fatty acid content of plasma cholesterol esters indicated a high plasma cholesterol linoleate level for infants fed formula and a reduced content of C20 and C22 omega 6 and omega 3 fatty acids. For infants fed the modified formula (LCPE-formula) the levels of 20:4 omega 6, 20:5 omega 3 and 22:6 omega 3 were higher than observed for the formula group and similar to those observed for infants fed EBM. By the fifth week of life, feeding the modified formula resulted in plasma phospholipid levels of C20 and C22 omega 6 and omega 3 fatty acids similar to levels of C20 and C22 omega 6 and omega 3 fatty acids found in infants fed EBM and significantly higher than levels characteristic of infants fed formula. It is concluded that infants fed LCPE-formula illustrate an overall balance between C20 and C22 omega 6 to omega 3 fatty acids in the plasma similar to that characteristic of infants fed human milk.
34名出生时体重不足1500克的早产儿被喂食早产配方奶粉（配方奶）、按照人乳特征范围内含有平衡的C20和C22ω-6和ω-3脂肪酸的早产婴儿配方奶粉（LCPE配方奶）或其母亲挤出的母乳（EBM）。在出生后第一周和喂养28天后采集血样，以确定喂食C20和C22ω-6和ω-3脂肪酸对血浆脂质的影响。红细胞磷脂的脂肪酸分析表明，饮食治疗和年龄之间差异不大。血浆胆固醇酯的脂肪酸含量表明，喂食配方奶的婴儿血浆胆固醇亚油酸水平较高，而C20和C22ω-6和ω-3脂肪酸含量降低。对于喂食改良配方奶（LCPE配方奶）的婴儿，20:4ω-6、20:5ω-3和22:6ω-3的水平高于配方奶组，与喂食EBM的婴儿相似。到出生后第五周，喂食改良配方奶使血浆中C20和C22ω-6和ω-3脂肪酸的磷脂水平与喂食EBM的婴儿中发现的C20和C22ω-6和ω-3脂肪酸水平相似，且显著高于喂食配方奶婴儿特征性的水平。得出的结论是，喂食LCPE配方奶的婴儿血浆中C20和C22ω-6至ω-3脂肪酸呈现出总体平衡，类似于喂食人乳婴儿的特征。
