Clandinin M T, Garg M L, Parrott A, Van Aerde J, Hervada A, Lien E
Department of Foods and Nutrition, University of Alberta, Edmonton, Canada.
Lipids. 1992 Nov;27(11):896-900. doi: 10.1007/BF02535869.
Thirty-four premature infants who were appropriate for gestational age and weighing less than 1500 g at birth were fed "preemie" SMA-24 formula, "preemie" SMA-24 formula manufactured to contain C20 and C22 omega 6 and omega 3 fatty acids (LCPE-SMA), or expressed milk (EBM). Blood samples were drawn from a small arm vein during the first week of life and after 28 days of feeding. The fatty acid content of plasma phospholipids was determined. Infants fed SMA-24 had a high content of 18:2 omega 6 in plasma phospholipids. Feeding LCPE-SMA normalized plasma phospholipid levels of C20 and C22 omega 6 and omega 3 fatty acids to be similar to levels of C20 and C22 omega 6 and omega 3 fatty acids found in infants fed EBM, and significantly higher than characteristic levels for infants fed SMA-24. Feeding LCPE-SMA or EBM results in a balanced incorporation of C20 and C22 omega 6 and omega 3 fatty acids into phospholipids derived from the liver or perhaps the small intestine.
34名适于胎龄、出生体重小于1500克的早产儿分别喂食“早产儿”SMA - 24配方奶粉、含有C20和C22ω6和ω3脂肪酸的“早产儿”SMA - 24配方奶粉（LCPE - SMA）或挤母乳（EBM）。在出生后第一周和喂食28天后从小臂静脉采集血样。测定血浆磷脂的脂肪酸含量。喂食SMA - 24的婴儿血浆磷脂中18:2ω6含量较高。喂食LCPE - SMA可使C20和C22ω6和ω3脂肪酸的血浆磷脂水平正常化，使其与喂食EBM的婴儿中发现的C20和C22ω6和ω3脂肪酸水平相似，且显著高于喂食SMA - 24的婴儿的特征水平。喂食LCPE - SMA或EBM可使C20和C22ω6和ω3脂肪酸平衡地掺入源自肝脏或可能是小肠的磷脂中。
