Henderson R A, Jensen R G, Lammi-Keefe C J, Ferris A M, Dardick K R
Department of Nutritional Sciences, University of Connecticut, Storrs 06269-4017.
Lipids. 1992 Nov;27(11):863-9. doi: 10.1007/BF02535865.
To examine the effect of fish oil supplementation on the fatty acid (FA) composition of human milk and maternal and infant erythrocytes, five lactating women were supplemented with 6 g of fish oil daily for 21 d. Usual maternal diets contained 1,147 mg of total n-3 FA, with 120 mg from very long-chain (> C18) n-3 FA. Supplementation increased dietary levels to 3,092 mg of total n-3 FA and 2,006 mg of very long-chain n-3 FA. Milk samples were collected daily, prior to fish oil ingestion, and at 4-h intervals on days 1, 7, 14 and 21. Milk n-3 FA content increased within 8 h and reached steady state levels within one week. The n-6 fatty acid content decreased. Erythrocyte eicosapentaenoic acid content increased from 0.24% to 1.4% (P < 0.01) in mothers and from 0.11% to 0.70% (P < 0.05) in infants. Docosapentaenoic acid increased from 1.4% to 2.2% (P < 0.05) in mothers and from 0.30% to 0.78% (P < 0.01) in infants. There was no significant change in docosahexaenoic acid or n-6 fatty acid content. Maternal platelet aggregation responses were variable. No differences in milk or plasma tocopherol levels were noted.
为研究补充鱼油对母乳以及母婴红细胞脂肪酸（FA）组成的影响，五名哺乳期妇女每天补充6克鱼油，持续21天。母亲的日常饮食中总n-3 FA含量为1147毫克，其中120毫克来自极长链（> C18）n-3 FA。补充后，饮食中总n-3 FA水平增至3092毫克，极长链n-3 FA水平增至2006毫克。每天在摄入鱼油前以及第1、7、14和21天每隔4小时采集一次母乳样本。母乳中n-3 FA含量在8小时内增加，并在一周内达到稳态水平。n-6脂肪酸含量下降。母亲红细胞中的二十碳五烯酸含量从0.24%增至1.4%（P < 0.01），婴儿红细胞中的该含量从0.11%增至0.70%（P < 0.05）。母亲红细胞中的二十二碳五烯酸含量从1.4%增至2.2%（P < 0.05），婴儿红细胞中的该含量从0.30%增至0.78%（P < 0.01）。二十二碳六烯酸或n-6脂肪酸含量无显著变化。母亲血小板聚集反应存在差异。未观察到母乳或血浆中生育酚水平有差异。
