Geurts Frederik J, De Schutter Erik, Dieudonné Stéphane
Laboratory of Theoretical Neurobiology, Born-Bunge Foundation, University of Antwerp-UIA, Antwerp, Belgium.
Cerebellum. 2003;2(4):290-9. doi: 10.1080/14734220310011948.
Neuronal network behaviors emerge from complex interactions between excitatory relay cells, principal cells and inhibitory interneurons. Therefore, characterizing homogeneous cell types and their properties is an essential step towards understanding information processing in the brain. The cerebellar cortex is generally described as a repetitive circuit composed of only five cell types. However, recent studies have revealed an unexpected diversity in the morphological, neurochemical and electrophysiological properties of the large-sized granular layer interneurons. These data are reviewed here with an emphasis on the synaptic interactions of the different cell types within the cerebellar cortex. The existence of a complex network of excitatory and inhibitory interneurons controlling the spatial and temporal pattern of granule cell firing is documented, providing insights into the cellular and synaptic processes underlying oscillations and synchronization in the cerebellar cortex.
神经元网络行为源自兴奋性中继细胞、主细胞和抑制性中间神经元之间的复杂相互作用。因此，表征同质性细胞类型及其特性是理解大脑信息处理过程的关键一步。小脑皮质通常被描述为仅由五种细胞类型组成的重复回路。然而，最近的研究揭示了大颗粒层中间神经元在形态、神经化学和电生理特性方面存在意想不到的多样性。本文对这些数据进行了综述，重点关注小脑皮质内不同细胞类型的突触相互作用。文中记录了一个控制颗粒细胞放电时空模式的兴奋性和抑制性中间神经元复杂网络的存在，这为深入了解小脑皮质振荡和同步背后的细胞和突触过程提供了线索。
