Kim Darrick S H L, Kim Jin Yung
Program for Collaborative Research in Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. dkim@curxcel@com
Bioorg Med Chem Lett. 2004 Mar 8;14(5):1287-9. doi: 10.1016/j.bmcl.2003.12.041.
Ten shogaols were synthesized to evaluate the importance of the side-chain length in protecting cells from betaA(1-42) insult using PC12 rat pheochromocytoma and IMR-32 human neuroblastoma cells. The compounds cell protectivity against betaA insult was demonstrated using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction assay. The efficacy of cell protection from betaA insult by these shogaols was shown to improve as the length of the side chain increase.
合成了十种姜辣素，以利用大鼠嗜铬细胞瘤PC12细胞和人神经母细胞瘤IMR-32细胞评估侧链长度在保护细胞免受β-淀粉样蛋白（1-42）损伤中的重要性。使用3-[4,5-二甲基噻唑-2-基]-2,5-二苯基四氮唑溴盐（MTT）还原试验证明了这些化合物对β-淀粉样蛋白损伤的细胞保护作用。结果表明，随着这些姜辣素侧链长度的增加，其对β-淀粉样蛋白损伤的细胞保护功效增强。
