抗艾滋病药物。第57部分：升麻素，一种从总状升麻（黑升麻）根茎中提取的抗HIV成分，以及相关皂苷的抗HIV活性。
Anti-AIDS agents. Part 57: Actein, an anti-HIV principle from the rhizome of Cimicifuga racemosa (black cohosh), and the anti-HIV activity of related saponins.
作者信息
Sakurai Nobuko, Wu Jiu-Hong, Sashida Yutaka, Mimaki Yoshihiro, Nikaido Tamotsu, Koike Kazuo, Itokawa Hideji, Lee Kuo-Hsiung
机构信息
Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7360, USA.
出版信息
Bioorg Med Chem Lett. 2004 Mar 8;14(5):1329-32. doi: 10.1016/j.bmcl.2003.12.035.
Actein (1), a tetracyclic triterpenoid from the rhizome of Cimicifuga racemosa (black cohosh), and 82 related triterpenoid and steroidal saponins isolated from higher plants were evaluated for anti-HIV activity as a continuing study to discover potential anti-AIDS agents from natural products. Actein showed potent activity and another twelve saponins showed moderate activity. The active compounds included two steroidal, seven tetracyclic triterpenoid, and four pentacyclic triterpenoid compounds.
从升麻（黑升麻）根茎中提取的四环三萜类化合物升麻素（1）以及从高等植物中分离得到的82种相关三萜类和甾体皂苷被评估其抗HIV活性，这是一项从天然产物中发现潜在抗艾滋病药物的持续研究。升麻素显示出强效活性，另有12种皂苷显示出中等活性。活性化合物包括两种甾体、七种四环三萜类和四种五环三萜类化合物。
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