一大群健康献血者中巨细胞病毒的持续血清学转换

Continuous cytomegalovirus seroconversion in a large group of healthy blood donors.

作者信息

Hecker M, Qiu D, Marquardt K, Bein G, Hackstein H

机构信息

Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig University Giessen, Giessen, Germany.

出版信息

Vox Sang. 2004 Jan;86(1):41-4. doi: 10.1111/j.0042-9007.2004.00388.x.

DOI:10.1111/j.0042-9007.2004.00388.x

PMID:14984558

Abstract

BACKGROUND AND OBJECTIVES

Transmission of cytomegalovirus (CMV) to seronegative, immunocompromised recipients can cause serious and fatal complications. Although the seroprevalence of CMV is high, the risk of primary CMV infection among healthy blood donors has not yet been analysed in a large population.

MATERIALS AND METHODS

We developed an algorithm to determine the rate of CMV seroconversion in an overall cohort of 24,260 subjects who donated 176,474 blood units during an 11-year observation period.

RESULTS

We detected CMV seroconversion in all relevant age groups (18-60 years) with an overall seroconversion rate of 0.55% per year. Both CMV seroconversion and seroprevalence occurred more frequently in female donors (P = 0.02 and P < 0.001, respectively). We identified 30-35-year-old blood donors as the group with the highest rate of CMV seroconversion per year (1.33% vs. 0.46%; P < 0.0001).

CONCLUSIONS

We conclude that the risk of primary CMV infection is a continuous lifelong event and correlates with age and female gender.

摘要

背景与目的

巨细胞病毒（CMV）传播给血清学阴性、免疫功能低下的受者可导致严重和致命的并发症。尽管CMV的血清阳性率很高，但尚未在大量人群中分析健康献血者中初次感染CMV的风险。

材料与方法

我们开发了一种算法，以确定在11年观察期内捐献了176,474单位血液的24,260名受试者的总体队列中CMV血清学转换率。

结果

我们在所有相关年龄组（18 - 60岁）中检测到CMV血清学转换，总体血清学转换率为每年0.55%。CMV血清学转换和血清阳性率在女性献血者中均更频繁出现（分别为P = 0.02和P < 0.001）。我们确定30 - 35岁的献血者是每年CMV血清学转换率最高的组（1.33%对0.46%；P < 0.0001）。