来自献血者的血浆输血在恒河猴中引发了戊型肝炎。
Transfusion of plasma from a blood donor induced hepatitis E in Rhesus monkey.
作者信息
Xia N-S, Zhang J, Zheng Y-J, Ge S-X, Ye X-Z, Ou S-H
机构信息
Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, China.
出版信息
Vox Sang. 2004 Jan;86(1):45-7. doi: 10.1111/j.0042-9007.2004.00377.x.
BACKGROUND AND OBJECTIVES
Hepatitis E virus (HEV) infection is normally transmitted via the faeco-oral route. The possibility that the infection might be transmissible by blood has been suggested. Direct evidence of blood-borne transmission of hepatitis E infection is, however, absent.
MATERIALS AND METHODS
In this report, 10 ml of plasma obtained from a healthy, but hepatitis E viraemic, blood donor was transfused to a Rhesus monkey.
RESULTS
Acute hepatitis E developed following transfusion of blood from the hepatitis E viraemic donor. This was confirmed by virological, immunological, biochemical and histopathological data.
CONCLUSIONS
These results, combined with other epidemiological findings previously reported, indicate that transfusion-associated hepatitis E can occur. The risk of transfusion-associated HEV infection in endemic areas should be assessed and strategies developed to reduce it.
背景与目的
戊型肝炎病毒（HEV）感染通常经粪-口途径传播。已有研究提示该感染可能通过血液传播。然而，尚无戊型肝炎经血液传播的直接证据。
材料与方法
在本报告中，将从一名健康但感染了戊型肝炎病毒血症的献血者采集的10毫升血浆输注给一只恒河猴。
结果
输注来自感染戊型肝炎病毒血症献血者的血液后，恒河猴发生了急性戊型肝炎。病毒学、免疫学、生化及组织病理学数据证实了这一点。
结论
这些结果与先前报道的其他流行病学发现相结合，表明可发生输血相关的戊型肝炎。应评估流行地区输血相关戊型肝炎病毒感染的风险，并制定降低该风险的策略。
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