Dong C, Sanchez L E, Price R A
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Int J Obes Relat Metab Disord. 2004 Jun;28(6):790-5. doi: 10.1038/sj.ijo.0802626.
To examine the relationship between obesity and depression in a sample of extremely obese individuals and their siblings and parents.
A total of 1730 European Americans (558 men, 1172 women, aged 49.29+/-15.42 y, body mass index (BMI) of 35.57+/-11.53 kg/m(2)) and 373 African Americans (103 men, 270 women, aged 44.85+/-15.08 years, BMI of 36.83+/-11.31 kg/m(2)) in a sample of 482 nuclear families segregating extreme obesity and normal weight.
Individual BMI, history of depression treatment and covariates (age, sex, race, education, marital status, socioeconomic status, chronic medical conditions and exercise program).
Greater odds for depression were found for the obese, European American, women, the unmarried, the more educated, those with chronic physical disorder(s) and the offspring of depressed parents. A trend test found that the odds ratios for depression increased with BMI and number of chronic medical conditions (P<0.0001). Multivariate logistic regression analyses indicated that BMI, race, marital status, chronic medical conditions and family history were the predicators of depression for both the genders. Hierarchical analyses revealed that BMI significantly increased the risk above that predicated by the combined effects of all other variables.
Extreme obesity was associated with the increased risk for depression across gender and racial groups, even after controlling for chronic physical disease, familial depression and demographic risk factors. More detailed research is needed to determine the underlying mechanisms.
在极度肥胖个体及其兄弟姐妹和父母的样本中研究肥胖与抑郁之间的关系。
在482个分离出极度肥胖和正常体重个体的核心家庭样本中，共有1730名欧裔美国人（558名男性，1172名女性，年龄49.29±15.42岁，体重指数（BMI）为35.57±11.53kg/m²）和373名非裔美国人（103名男性，270名女性，年龄44.85±15.08岁，BMI为36.83±11.31kg/m²）。
个体BMI、抑郁治疗史及协变量（年龄、性别、种族、教育程度、婚姻状况、社会经济地位、慢性疾病情况和运动项目）。
肥胖者、欧裔美国人、女性、未婚者、受教育程度较高者、患有慢性身体疾病者以及父母患有抑郁症的后代患抑郁症的几率更高。趋势检验发现，抑郁症的比值比随BMI和慢性疾病数量的增加而升高（P<0.0001）。多因素逻辑回归分析表明，BMI、种族、婚姻状况、慢性疾病情况和家族史是男女抑郁症的预测因素。分层分析显示，BMI显著增加了高于所有其他变量综合作用所预测的风险。
即使在控制了慢性身体疾病、家族性抑郁症和人口统计学风险因素之后，极度肥胖在不同性别和种族群体中均与抑郁症风险增加相关。需要更详细的研究来确定其潜在机制。
