Wong Tze-wai, Lee Chin-kei, Tam Wilson, Lau Joseph Tak-fai, Yu Tak-sun, Lui Siu-fai, Chan Paul K S, Li Yuguo, Bresee Joseph S, Sung Joseph J Y, Parashar Umesh D
Departmentof Community and Family Medicine, The Chinese University of Hong Kong, School of Public Health, Prince of Wales Hospital, Hong Kong Special Administrative Region, People's Republic of China.
Emerg Infect Dis. 2004 Feb;10(2):269-76. doi: 10.3201/eid1002.030452.
We studied transmission patterns of severe acute respiratory syndrome (SARS) among medical students exposed exclusively to the first SARS patient in the Prince of Wales Hospital in Hong Kong, before his illness was recognized. We conducted a retrospective cohort study of 66 medical students who visited the index patient's ward, including 16 students with SARS and 50 healthy students. The risk of contracting SARS was sevenfold greater among students who definitely visited the index case's cubicle than in those who did not (10/27 [41%] versus 1/20 [5%], relative risk 7.4; 95% confidence interval 1.0 to 53.3). Illness rates increased directly with proximity of exposure to the index case. However, four of eight students who were in the same cubicle, but were not within 1 m of the index case-patient, contracted SARS. Proximity to the index case-patient was associated with transmission, which is consistent with droplet spread. Transmission through fomites or small aerosols cannot be ruled out.
我们研究了在香港威尔士亲王医院首位严重急性呼吸综合征（SARS）患者病情被确诊之前，仅接触过该患者的医科学生中的SARS传播模式。我们对66名前往该首例患者病房的医科学生进行了一项回顾性队列研究，其中包括16名感染SARS的学生和50名健康学生。明确去过首例患者小隔间的学生感染SARS的风险比未去过的学生高7倍（10/27 [41%] 对比1/20 [5%]，相对风险7.4；95%置信区间1.0至53.3）。发病率随与首例患者接触的密切程度直接上升。然而，在同一小隔间但与首例患者距离未达1米的8名学生中有4人感染了SARS。与首例患者的近距离接触与传播相关，这与飞沫传播相符。不能排除通过污染物或小气溶胶传播的可能性。
