Morgan J, Williams P, Norris F, Williams C M, Larkin M, Hampton S
School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.
Arch Dis Child. 2004 Apr;89(4):309-14. doi: 10.1136/adc.2002.020065.
To establish whether development of eczema is influenced by feeding practices in preterm infants, while taking account of confounding factors.
Data were assembled from 257 infants born prematurely and studied to 12 months post-term. Logistic regression analysis was performed to establish the association between feeding practices and eczema, allowing for potential confounding factors including the infants' gender, parental atopic status, social background, and parental smoking habits.
For the development of eczema (with or without other symptoms) by 12 months post-term, the introduction of four or more solid foods by or before 17 weeks post-term was a significant risk (odds ratio 3.49). Male infants were at significantly higher risk (odds ratio 1.84). In addition, having non-atopic parents who introduced solid foods before 10 weeks post-term or having at least one atopic parent represented a significant risk scenario (odds ratio 2.94).
Early introduction of a diverse range of solid foods may predispose the preterm infant to eczema development by 12 months post-term. Furthermore, non-atopic parents who practice early as opposed to late introduction of solid foods may be exposing preterm infants to a greater risk of eczema by 12 months post-term.
在考虑混杂因素的情况下，确定湿疹的发生是否受早产儿喂养方式的影响。
收集了257名早产儿的数据，并对其进行至足月后12个月的研究。进行逻辑回归分析以确定喂养方式与湿疹之间的关联，同时考虑包括婴儿性别、父母特应性状态、社会背景和父母吸烟习惯等潜在混杂因素。
对于足月后12个月时湿疹（有或无其他症状）的发生，在足月后17周或之前引入四种或更多固体食物是一个显著风险因素（比值比3.49）。男婴的风险显著更高（比值比1.84）。此外，非特应性父母在足月后10周之前引入固体食物或至少有一位特应性父母，均代表显著的风险情况（比值比2.94）。
在足月后12个月之前过早引入多种固体食物可能使早产儿易患湿疹。此外，与晚引入固体食物相比，过早引入固体食物的非特应性父母可能使早产儿在足月后12个月患湿疹的风险更高。
