花粉热、湿疹与喘息：一项英国全国性研究（儿童哮喘与过敏国际研究，ISAAC）
Hay fever, eczema, and wheeze: a nationwide UK study (ISAAC, international study of asthma and allergies in childhood).
作者信息
Austin J B, Kaur B, Anderson H R, Burr M, Harkins L S, Strachan D P, Warner J O
机构信息
Department of Child Health, Highland Primary Care NHS Trust, Royal Northern Infirmary, Inverness IV3 5SF, UK.
出版信息
Arch Dis Child. 1999 Sep;81(3):225-30. doi: 10.1136/adc.81.3.225.
OBJECTIVES
To describe the prevalence of atopic symptoms in children throughout the UK.
METHOD
A questionnaire survey of 12-14 year olds throughout England, Wales, Scotland, and the Scottish Islands using the international study of asthma and allergies in childhood (ISAAC) protocol.
RESULTS
A total of 27 507 (86%) children took part. Recent rhinoconjunctivitis was reported by 18.2%, with 6.2% reporting symptoms between March and September; 16.4% reported itchy flexural rash in the past 12 months. The prevalence of atopic symptoms was higher in girls and subjects born within the UK. The prevalence of severe wheeze was highest in subjects reporting perennial rhinoconjunctivitis, as opposed to summertime only symptoms. Winter rhinoconjunctivitis was associated with severe wheeze and severe flexural rash. One or more current symptoms were reported by 47.6% of all children and 4% reported all three symptoms.
CONCLUSION
In general, geographical variations were small but the prevalence of symptoms was significantly higher in Scotland and northern England. The study demonstrates the importance of atopic diseases both in their own right and in association with asthma.
目的
描述全英国儿童特应性症状的患病率。
方法
采用儿童哮喘和过敏国际研究（ISAAC）方案，对英格兰、威尔士、苏格兰和苏格兰岛屿的12至14岁儿童进行问卷调查。
结果
共有27507名（86%）儿童参与。18.2%的儿童报告近期患有鼻结膜炎，其中6.2%的儿童报告在3月至9月期间出现症状；16.4%的儿童报告在过去12个月内有瘙痒性屈侧皮疹。特应性症状的患病率在女孩和在英国出生的儿童中更高。常年性鼻结膜炎患儿的重度喘息患病率最高，而仅在夏季出现症状的患儿患病率则相反。冬季鼻结膜炎与重度喘息和重度屈侧皮疹有关。47.6%的儿童报告有1种或多种当前症状，4%的儿童报告有所有3种症状。
结论
总体而言，地域差异较小，但苏格兰和英格兰北部的症状患病率明显更高。该研究证明了特应性疾病本身以及与哮喘相关的重要性。
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