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白色念珠菌的SKN7：突变体构建与表型分析。

SKN7 of Candida albicans: mutant construction and phenotype analysis.

作者信息

Singh Praveen, Chauhan Neeraj, Ghosh Anup, Dixon Freddie, Calderone Richard

机构信息

Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA.

出版信息

Infect Immun. 2004 Apr;72(4):2390-4. doi: 10.1128/IAI.72.4.2390-2394.2004.

DOI:10.1128/IAI.72.4.2390-2394.2004
PMID:15039366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC375215/
Abstract

The SKN7 two-component response regulator gene of Candida albicans was deleted, and the phenotype of the mutant was established. This mutant exhibited impaired growth on Spider agar and 10% serum agar compared to wild-type and gene-reconstituted strains. The skn7 mutant was sensitive to H(2)O(2) in vitro, but its virulence was only mildly attenuated. A comparison of the Skn7p and Ssk1p response regulators of C. albicans is discussed.

摘要

白色念珠菌的双组分反应调节基因SKN7被敲除，并确定了突变体的表型。与野生型和基因重组菌株相比，该突变体在蜘蛛琼脂和10%血清琼脂上生长受损。skn7突变体在体外对H₂O₂敏感，但其毒力仅轻度减弱。文中讨论了白色念珠菌的Skn7p和Ssk1p反应调节因子的比较。

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本文引用的文献

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Candida albicans response regulator gene SSK1 regulates a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress.白色念珠菌应答调节基因SSK1调控了一组基因，这些基因的功能与细胞壁生物合成及对氧化应激的适应性相关。
Eukaryot Cell. 2003 Oct;2(5):1018-24. doi: 10.1128/EC.2.5.1018-1024.2003.
2
Regulation of the transcriptional response to oxidative stress in fungi: similarities and differences.真菌中对氧化应激转录反应的调控：异同点
Eukaryot Cell. 2003 Jun;2(3):381-9. doi: 10.1128/EC.2.3.381-389.2003.
3
The role of the Candida albicans histidine kinase [CHK1) gene in the regulation of cell wall mannan and glucan biosynthesis.白色念珠菌组氨酸激酶[CHK1]基因在细胞壁甘露聚糖和葡聚糖生物合成调控中的作用。
FEMS Yeast Res. 2003 May;3(3):289-99. doi: 10.1111/j.1567-1364.2003.tb00170.x.
4
Stress-induced gene expression in Candida albicans: absence of a general stress response.白色念珠菌中应激诱导的基因表达：缺乏一般应激反应。
Mol Biol Cell. 2003 Apr;14(4):1460-7. doi: 10.1091/mbc.e02-08-0546.
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The Hog1 mitogen-activated protein kinase is essential in the oxidative stress response and chlamydospore formation in Candida albicans.Hog1丝裂原活化蛋白激酶在白色念珠菌的氧化应激反应和厚垣孢子形成过程中至关重要。
Eukaryot Cell. 2003 Apr;2(2):351-61. doi: 10.1128/EC.2.2.351-361.2003.
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