Bowman S J, Booth D A, Platts R G
University of Birmingham, Rheumatology Department, UK.
Rheumatology (Oxford). 2004 Jun;43(6):758-64. doi: 10.1093/rheumatology/keh170. Epub 2004 Mar 23.
Fatigue is a prominent symptom in primary Sjögren's syndrome (PSS). We set out to compare existing instruments and a new tool for measuring fatigue and general discomfort in PSS, with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and healthy controls.
Groups of female Caucasian PSS patients completed a new questionnaire developed from PSS patients' own vocabulary, as well as the SF-36, WHOQOL-BREF and HAD scales. For comparison, the questionnaire was also completed by groups of SLE and RA patients and healthy controls.
Each disease group differed significantly from healthy controls on each facet of fatigue and general discomfort in the new tool. Somatic fatigue was worst in RA, while mental fatigue was worst in PSS and SLE. The facets of somatic fatigue and discomfort in the new tool correlated well with comparable domains in existing scales.
Fatigue in PSS can be measured using this new Sjögren's-based psychometric instrument. The new questionnaire tool was more sensitive than the SF-36, WHOQOL-BREF and HAD at distinguishing the three rheumatic disorders from controls.
疲劳是原发性干燥综合征（PSS）的一个突出症状。我们着手比较现有的测量工具以及一种用于测量PSS患者疲劳和全身不适的新工具，并与系统性红斑狼疮（SLE）、类风湿关节炎（RA）患者及健康对照进行比较。
白人女性PSS患者组完成了一份根据PSS患者自身词汇编制的新问卷，以及SF-36、世界卫生组织生活质量简表（WHOQOL-BREF）和医院焦虑抑郁量表（HAD）。为作比较，SLE患者组、RA患者组及健康对照组也完成了这份问卷。
在新工具中，每个疾病组在疲劳和全身不适的各个方面与健康对照均有显著差异。躯体疲劳在RA中最严重，而精神疲劳在PSS和SLE中最严重。新工具中躯体疲劳和不适的方面与现有量表中的可比领域相关性良好。
可使用这种基于干燥综合征的新心理测量工具来测量PSS中的疲劳。在区分这三种风湿性疾病与对照方面，新问卷工具比SF-36、WHOQOL-BREF和HAD更敏感。
