铜催化的亚胺、酰氯和炔烃的偶联反应：合成炔丙基酰胺的多组分路线。
Copper-catalyzed coupling of imines, acid chlorides, and alkynes: a multicomponent route to propargylamides.
作者信息
Black Daniel A, Arndtsen Bruce A
机构信息
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada.
出版信息
Org Lett. 2004 Apr 1;6(7):1107-10. doi: 10.1021/ol036462+.
PMID:15040734
Abstract
The use of imines in a metal-catalyzed coupling with alkynes and acid chlorides is described. This process proceeds rapidly with CuI as the catalyst and provides an efficient and general three-component coupling method to prepare propargylamides. The coupling can also be diversified to allow the formation of N-carbamate-protected propargylamines with the use of chloroformates.
摘要
本文描述了亚胺在金属催化下与炔烃和酰氯的偶联反应。该反应以碘化亚铜为催化剂迅速进行，提供了一种高效通用的三组分偶联方法来制备炔丙酰胺。通过使用氯甲酸酯，该偶联反应还可以多样化，以形成N-氨基甲酸酯保护的炔丙胺。
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