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韩国人群桡骨远端和跟骨骨密度的患病率及危险因素

Prevalence and risk factors of distal radius and calcaneus bone mineral density in Korean population.

作者信息

Shin Aesun, Choi Ji-Yeob, Chung Hye-Won, Park Sue Kyung, Shin Chan Soo, Choi Yoon-Ho, Cho Sung-Il, Kim Dae-Sung, Kim Dong-Il, Lee Kyoung-Mu, Lee Kyoung Ho, Yoo Keun-Young, Kang Daehee

机构信息

Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon-Dong Chongno-Gu, 110-799, Korea.

出版信息

Osteoporos Int. 2004 Aug;15(8):639-44. doi: 10.1007/s00198-004-1587-4. Epub 2004 Mar 24.

DOI:10.1007/s00198-004-1587-4
PMID:15042282
Abstract

To estimate the prevalence and the related risk factors of low bone mineral density of the calcaneus and the distal radius, a community-based study was conducted in three rural areas of Korea. A total of 1420 women and 732 men aged 40 years and older participated in this study. Information on sociodemographic characteristics and the potential risk factors for osteoporosis were collected by an interviewer-administered standardized questionnaire. Bone mineral density (BMD) of the calcaneus and the distal radius were measured by dual-energy X-ray absorptiometry (DXA). Three hundred and seventeen women and 183 men aged 20-29 years who participated in a regular health check-up were used as a reference population. Osteoporosis was defined using WHO criteria. Odds ratios of the risk factors of osteoporosis were calculated by the unconditional logistic regression model. The standardized prevalence of osteoporosis of the calcaneus was 8.4% for males and 27.3% for females using the Korean population of year 2000 as a standard population. The standardized prevalence of osteoporosis of the distal radius was 4.2% for males and 18.8% for females. Older age and lower body mass index (BMI) were related with low BMD in both the calcaneus and distal radius in males and females. The duration after menopause and the number of live births were an independent risk factor for osteoporosis of the calcaneus (OR = 1.1, 95% CI = 1.00-1.11; the duration after menopause; OR = 2.0, 95% CI = 1.20-3.35, the number of live birth) and a familial history of non-traumatic fractures or osteoporosis among the first-degree relatives was significantly related to a increased risk of osteoporosis of the distal radius in females (OR = 2.9, 95% CI = 1.36-6.31).

摘要

为了评估跟骨和桡骨远端骨密度低的患病率及相关危险因素,在韩国的三个农村地区开展了一项基于社区的研究。共有1420名40岁及以上的女性和732名40岁及以上的男性参与了本研究。通过访员管理的标准化问卷收集社会人口学特征信息和骨质疏松症的潜在危险因素。采用双能X线吸收法(DXA)测量跟骨和桡骨远端的骨密度。将参加定期健康检查的183名20 - 29岁男性和317名20 - 29岁女性作为参照人群。根据世界卫生组织标准定义骨质疏松症。采用无条件逻辑回归模型计算骨质疏松症危险因素的比值比。以2000年韩国人群作为标准人群,跟骨骨质疏松症的标准化患病率男性为8.4%,女性为27.3%。桡骨远端骨质疏松症的标准化患病率男性为4.2%,女性为18.8%。年龄较大和体重指数(BMI)较低与男性和女性跟骨及桡骨远端的低骨密度有关。绝经后的持续时间和活产次数是跟骨骨质疏松症的独立危险因素(比值比=1.1,95%置信区间=1.00 - 1.11;绝经后的持续时间;比值比=2.0,95%置信区间=1.20 - 3.35,活产次数),一级亲属中有非创伤性骨折或骨质疏松症家族史与女性桡骨远端骨质疏松症风险增加显著相关(比值比=2.9,95%置信区间=1.36 - 6.31)。

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