Ottaway C A, Husband A J
Department of Medicine, University of Toronto, Ontario, Canada.
Brain Behav Immun. 1992 Jun;6(2):97-116. doi: 10.1016/0889-1591(92)90011-c.
The immune response network is only one of many physiologic adaptive responses to environmental change and there is now substantial evidence that adaptive responses involving the central nervous system have an impact on immune outcome. Effective immune function depends upon a highly mobile population of precursor and effector cells of the lymphoid system. In this review it is proposed that many of the alterations in immunity resulting from CNS activity may be explained in terms of changes in lymphocyte migration patterns in response to endocrine signals, neural signals via neurotransmitter release, or direct contacts between nerves and cells of the immune system.
免疫反应网络只是对环境变化的众多生理适应性反应之一，现在有大量证据表明，涉及中枢神经系统的适应性反应会对免疫结果产生影响。有效的免疫功能依赖于淋巴系统中高度可移动的前体细胞和效应细胞群体。在本综述中，有人提出，中枢神经系统活动导致的许多免疫改变，可能可以从淋巴细胞迁移模式的变化来解释，这些变化是对内分泌信号、通过神经递质释放的神经信号，或神经与免疫系统细胞之间的直接接触的反应。
