Friedman E M, Irwin M R
Department of Psychiatry, University of California, San Diego, USA.
Pharmacol Ther. 1997;74(1):27-38. doi: 10.1016/s0163-7258(96)00200-8.
This review discusses some of the major findings implicating the autonomic nervous system in the regulation of immune function. The sympathetic nervous system, the primary focus of this line of research, directly innervates the major lymphoid organs, and physiological release of sympathetic neurohormones at these sites has been documented. Leukocytes have been shown to express receptors for catecholamines, as well as neuropeptide Y, and studies in vitro and in vivo have indicated that occupation of these receptors by the appropriate ligands produces functional changes in immunological cells. Finally, altered sympathetic regulation may underlie some of the immunological abnormalities observed in chronic stress, clinical depression, and ageing.
本综述讨论了自主神经系统在免疫功能调节中的一些主要研究发现。作为这一研究方向的主要关注点，交感神经系统直接支配主要的淋巴器官，并且已证明这些部位存在交感神经激素的生理性释放。白细胞已被证明可表达儿茶酚胺以及神经肽Y的受体，体外和体内研究均表明，合适的配体占据这些受体可使免疫细胞产生功能变化。最后，交感神经调节改变可能是慢性应激、临床抑郁症和衰老过程中观察到的一些免疫异常的潜在原因。
