DNA多态性分析可区分引起人类黑热病的杜氏利什曼原虫分离株与引起黑热病后皮肤利什曼病的分离株。
DNA polymorphism assay distinguishes isolates of Leishmania donovani that cause kala-azar from those that cause post-kala-azar dermal Leishmaniasis in humans.
作者信息
Sreenivas Gannavaram, Raju B V Subba, Singh Ruchi, Selvapandiyan Angamuthu, Duncan Robert, Sarkar Dwijen, Nakhasi Hira L, Salotra Poonam
机构信息
Institute of Pathology (ICMR), Safdarjung Hospital Campus, New Delhi, India.
出版信息
J Clin Microbiol. 2004 Apr;42(4):1739-41. doi: 10.1128/JCM.42.4.1739-1741.2004.
Abstract
Leishmania donovani in India causes visceral infection (kala-azar) and dermal infection (post-kala-azar dermal leishmaniasis). We report here the identification of polymorphism in a well-defined genetic locus among the Leishmania parasites causing the visceral and dermal manifestations, in a comparison of 15 post-kala-azar dermal leishmaniasis and 12 kala-azar patient isolates.
摘要
在印度，杜氏利什曼原虫可引发内脏感染（黑热病）和皮肤感染（黑热病后皮肤利什曼病）。在本文中，我们报告了对15例黑热病后皮肤利什曼病患者分离株和12例黑热病患者分离株进行比较后，在引发内脏和皮肤症状的利什曼原虫中一个明确遗传位点上多态性的鉴定结果。
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