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DNA多态性分析可区分引起人类黑热病的杜氏利什曼原虫分离株与引起黑热病后皮肤利什曼病的分离株。

DNA polymorphism assay distinguishes isolates of Leishmania donovani that cause kala-azar from those that cause post-kala-azar dermal Leishmaniasis in humans.

作者信息

Sreenivas Gannavaram, Raju B V Subba, Singh Ruchi, Selvapandiyan Angamuthu, Duncan Robert, Sarkar Dwijen, Nakhasi Hira L, Salotra Poonam

机构信息

Institute of Pathology (ICMR), Safdarjung Hospital Campus, New Delhi, India.

出版信息

J Clin Microbiol. 2004 Apr;42(4):1739-41. doi: 10.1128/JCM.42.4.1739-1741.2004.

DOI:10.1128/JCM.42.4.1739-1741.2004
PMID:15071036
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC387559/
Abstract

Leishmania donovani in India causes visceral infection (kala-azar) and dermal infection (post-kala-azar dermal leishmaniasis). We report here the identification of polymorphism in a well-defined genetic locus among the Leishmania parasites causing the visceral and dermal manifestations, in a comparison of 15 post-kala-azar dermal leishmaniasis and 12 kala-azar patient isolates.

摘要

在印度，杜氏利什曼原虫可引发内脏感染（黑热病）和皮肤感染（黑热病后皮肤利什曼病）。在本文中，我们报告了对15例黑热病后皮肤利什曼病患者分离株和12例黑热病患者分离株进行比较后，在引发内脏和皮肤症状的利什曼原虫中一个明确遗传位点上多态性的鉴定结果。

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DNA polymorphism assay distinguishes isolates of Leishmania donovani that cause kala-azar from those that cause post-kala-azar dermal Leishmaniasis in humans.DNA多态性分析可区分引起人类黑热病的杜氏利什曼原虫分离株与引起黑热病后皮肤利什曼病的分离株。
J Clin Microbiol. 2004 Apr;42(4):1739-41. doi: 10.1128/JCM.42.4.1739-1741.2004.
2
Nested PCR assay for detection of Leishmania donovani in slit aspirates from post-kala-azar dermal Leishmaniasis Lesions.用于检测黑热病后皮肤利什曼病病变部位皮肤刮取物中杜氏利什曼原虫的巢式聚合酶链反应检测法。
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本文引用的文献

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Parasite detection in patients with post kala-azar dermal leishmaniasis in India: a comparison between molecular and immunological methods.印度黑热病后皮肤利什曼病患者的寄生虫检测：分子方法与免疫方法的比较
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Persistence without pathology in phosphoglycan-deficient Leishmania major.缺乏磷酸聚糖的硕大利什曼原虫无病理状态下的持续性
Science. 2003 Aug 29;301(5637):1241-3. doi: 10.1126/science.1087499.
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Post-kala-azar dermal leishmaniasis.黑热病后皮肤利什曼病
Lancet Infect Dis. 2003 Feb;3(2):87-98. doi: 10.1016/s1473-3099(03)00517-6.
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Strain typing in Leishmania donovani by using sequence-confirmed amplified region analysis.利用序列确认扩增区域分析对杜氏利什曼原虫进行菌株分型。
Int J Parasitol. 2002 Sep;32(10):1267-76. doi: 10.1016/s0020-7519(02)00091-7.
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The increase in risk factors for leishmaniasis worldwide.全球范围内利什曼病风险因素的增加。
Trans R Soc Trop Med Hyg. 2001 May-Jun;95(3):239-43. doi: 10.1016/s0035-9203(01)90223-8.
6
Genetic typing and phylogeny of the Leishmania donovani complex by restriction analysis of PCR amplified gp63 intergenic regions.通过对PCR扩增的gp63基因间区域进行限制性分析对杜氏利什曼原虫复合体进行基因分型和系统发育分析
Parasitology. 2001 Apr;122(Pt 4):393-403. doi: 10.1017/s0031182001007466.
7
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J Clin Microbiol. 2001 Mar;39(3):849-54. doi: 10.1128/JCM.39.3.849-854.2001.
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Leishmania donovani: intraspecific polymorphisms of Sudanese isolates revealed by PCR-based analyses and DNA sequencing.杜氏利什曼原虫：基于PCR分析和DNA测序揭示的苏丹分离株的种内多态性
Exp Parasitol. 2001 Jan;97(1):35-44. doi: 10.1006/expr.2001.4592.
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Gp63 gene polymorphism and population structure of Leishmania donovani complex: influence of the host selection pressure?杜氏利什曼原虫复合体的Gp63基因多态性与群体结构：宿主选择压力的影响？
Parasitology. 2001 Jan;122 Pt 1:25-35. doi: 10.1017/s0031182000007125.
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Genetic variability within the species Leishmania aethiopica does not correlate with clinical variations of cutaneous leishmaniasis.埃塞俄比亚利什曼原虫物种内的基因变异性与皮肤利什曼病的临床变异不相关。
Mol Biochem Parasitol. 2000 Mar 5;106(2):239-48. doi: 10.1016/s0166-6851(99)00216-9.