从虎杖植物中提取的两种新型细菌DNA引发酶抑制剂。
Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum.
作者信息
Hegde Vinod R, Pu Haiyan, Patel Mahesh, Black Todd, Soriano Aileen, Zhao Wenjun, Gullo Vincent P, Chan Tze-Ming
机构信息
Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
出版信息
Bioorg Med Chem Lett. 2004 May 3;14(9):2275-7. doi: 10.1016/j.bmcl.2004.02.006.
The 70% aqueous methanolic extract of the Peruvian plant Polygonum cuspidatum sp. was found to contain two novel phenolic saccharides 1 and 2, which were identified as inhibitors of the bacterial DNA primase enzyme. Structures of these two compounds were established based on high resolution NMR studies. Compound 1 and 2 inhibited the primase enzyme with an IC(50) of 4 and 5 microM, respectively.
秘鲁植物虎杖（Polygonum cuspidatum sp.）的70%甲醇水溶液提取物被发现含有两种新型酚类糖1和2，它们被鉴定为细菌DNA引发酶的抑制剂。基于高分辨率核磁共振研究确定了这两种化合物的结构。化合物1和2对引发酶的抑制作用的半数抑制浓度（IC50）分别为4和5微摩尔。
Zotero 插件