Erdmann T, Schwarz U S
Max Planck Institute of Colloids and Interfaces, D-14424 Potsdam, Germany.
Phys Rev Lett. 2004 Mar 12;92(10):108102. doi: 10.1103/PhysRevLett.92.108102. Epub 2004 Mar 10.
We solve the stochastic equations for a cluster of parallel bonds with shared constant loading, rebinding, and the completely dissociated state as an absorbing boundary. In the small force regime, cluster lifetime grows only logarithmically with bond number for weak rebinding, but exponentially for strong rebinding. Therefore rebinding is essential to ensure physiological lifetimes. The number of bonds decays exponentially with time for most cases, but in the intermediate force regime a small increase in loading can lead to much faster decay. This effect might be used by cell-matrix adhesions to induce signaling events through cytoskeletal loading.
我们求解了一组具有共享恒定负载、重新结合以及以完全解离状态作为吸收边界的平行键的随机方程。在小力 regime 中，对于弱重新结合，簇寿命仅随键数呈对数增长，但对于强重新结合则呈指数增长。因此，重新结合对于确保生理寿命至关重要。在大多数情况下，键的数量随时间呈指数衰减，但在中等力 regime 中，负载的小幅增加可能导致更快的衰减。细胞与基质的粘附可能利用这种效应通过细胞骨架负载来诱导信号事件。
