Tyan M L
West Los Angeles Veterans Affairs Medical Center 90073.
Proc Soc Exp Biol Med. 1992 Sep;200(4):487-9. doi: 10.3181/00379727-200-43458.
Pregnant mice congenic with C57BL/10 (B10.A, B10.BR, B10.D2, B10.A[2R], B10.A[5R], B10.A[15Rd, B10.A[1R], B10.A[18R], and B10.0L) were fed Purina Mouse Chow or the same diet plus 200 IU of vitamin A daily. The pregnant dams were sacrificed on the eighteenth day of gestation, and the fetuses were sexed and examined for defects in neural tube development. The frequency of neural tube defects was low (mean frequency of all strains, 0.36%) and was not affected by the addition of vitamin A (200 IU/day) to the diet. Twenty-seven of the 29 defects observed occurred in the anterior tube (exencephaly); fourteen were identified in female fetuses, but the sex could not be determined in the other 15 cases because of fetal death and early autolysis. Variations in frequency among the strains suggest that a locus between E beta and H-2D has a moderate influence on the occurrence of neural tube defects. Strains that had H-2d alleles in this segment of the H-2 complex had relatively high frequencies, and those with H-2b or H-2k alleles had significantly lower frequencies.
与C57BL/10同基因的怀孕小鼠（B10.A、B10.BR、B10.D2、B10.A[2R]、B10.A[5R]、B10.A[15Rd、B10.A[1R]、B10.A[18R]和B10.0L）喂食普瑞纳小鼠饲料或相同饲料并每日添加200国际单位维生素A。怀孕母鼠在妊娠第18天处死，对胎儿进行性别鉴定并检查神经管发育缺陷情况。神经管缺陷的发生率较低（所有品系的平均发生率为0.36%），且饲料中添加维生素A（200国际单位/天）对其无影响。观察到的29个缺陷中有27个发生在前神经管（无脑畸形）；14个在雌性胎儿中发现，但另外15例因胎儿死亡和早期自溶无法确定性别。各品系间发生率的差异表明，Eβ和H-2D之间的一个基因座对神经管缺陷的发生有中等程度影响。H-2复合体这一区域具有H-2d等位基因的品系发生率相对较高，而具有H-2b或H-2k等位基因的品系发生率则显著较低。
