Tyan M L
Veterans Affairs Medical Center, Los Angeles, California 90073, USA.
Proc Soc Exp Biol Med. 1995 Oct;210(1):77-80. doi: 10.3181/00379727-210-43927.
Pregnant H-2 congenic mice, C57BL/10, B10.A, B10.A(15R), and B10.A(18R) were fed Purina Laboratory Chow 5001 or the same diet supplemented with 400 IU vitamin A dissolved in corn oil or 0.4% (w/w) myo-inositol. On the 18th day of gestation, the dams were sacrificed, and the fetuses were weighted, sexed, and examined for developmental abnormalities. Term fetal weight was found to be significantly reduced in progeny of dams bearing d alleles distal to Ea in the H-2 complex when the diet was supplemented with vitamin A or myo-inositol (B10.A and B10.A [18R]). Fetuses from dams of all strains fed the diet supplemented with vitamin A had significantly increased frequencies of microphthalmia; the frequency of microphthalmia was moderately but not significantly increased in one of the two strains fed the diet supplemented with myo-inositol (B10.A[15R] but not B10.A[18R]).
将怀孕的H-2同源基因小鼠C57BL/10、B10.A、B10.A(15R)和B10.A(18R)喂食普瑞纳实验室饲料5001，或喂食添加了溶于玉米油的400国际单位维生素A或0.4%（重量/重量）肌醇的相同饲料。在妊娠第18天，处死母鼠，对胎儿进行称重、性别鉴定，并检查是否有发育异常。当饲料中添加维生素A或肌醇时，发现携带H-2复合体中Ea远端d等位基因的母鼠后代的足月胎儿体重显著降低（B10.A和B10.A[18R]）。所有喂食添加维生素A饲料的品系母鼠所产胎儿的小眼症发生率显著增加；在喂食添加肌醇饲料的两个品系之一（B10.A[15R]而非B10.A[18R]）中，小眼症发生率适度增加但不显著。
