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新生大鼠海马体中γ-氨基丁酸能突触的可塑性

Plasticity of GABAergic synapses in the neonatal rat hippocampus.

作者信息

Gaïarsa J-L

机构信息

Institut de Neurobiologie de la Méditerranée (INMED), Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 29, Marseille, France.

出版信息

J Cell Mol Med. 2004 Jan-Mar;8(1):31-7. doi: 10.1111/j.1582-4934.2004.tb00257.x.

Abstract

While the development and plasticity of excitatory synaptic connections have been studied into detail, little is known about the development of inhibitory synapses. As proposed for excitatory synapses, recent studies have indicated that activity-dependent forms of synaptic plasticity, such as long-term potentiation and long-term depression, may play a role in the establishment of functional inhibitory synaptic connections. Here, I review these different forms of plasticity and focus on their possible role in the developing neuronal network.

摘要

虽然兴奋性突触连接的发育和可塑性已得到详细研究,但对于抑制性突触的发育却知之甚少。正如对兴奋性突触的推测一样,最近的研究表明,依赖活动的突触可塑性形式,如长时程增强和长时程抑制,可能在功能性抑制性突触连接的建立中发挥作用。在此,我将综述这些不同形式的可塑性,并着重探讨它们在发育中的神经元网络中可能发挥的作用。

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