Tick saliva reduces adherence and area of human neutrophils.
作者信息
Montgomery Ruth R, Lusitani Denise, De Boisfleury Chevance Anne, Malawista Stephen E
机构信息
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
出版信息
Infect Immun. 2004 May;72(5):2989-94. doi: 10.1128/IAI.72.5.2989-2994.2004.
Abstract
During natural infection with the agent of Lyme disease, Borrelia burgdorferi, spirochetes are delivered with vector saliva, which contains anti-inflammatory and antihemostatic activities. We show here that the saliva of ixodid ticks reduces polymorphonuclear leukocyte (PMN) adhesion via downregulation of beta2-integrins and decreases the efficiency of PMN in the uptake and killing of spirochetes. Inhibition of integrin adhesion and signaling reduces anti-inflammatory functions of PMN. These effects may favor the initial survival of spirochetes in vivo.
摘要
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