Montgomery Ruth R, Lusitani Denise, De Boisfleury Chevance Anne, Malawista Stephen E
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Infect Immun. 2004 May;72(5):2989-94. doi: 10.1128/IAI.72.5.2989-2994.2004.
During natural infection with the agent of Lyme disease, Borrelia burgdorferi, spirochetes are delivered with vector saliva, which contains anti-inflammatory and antihemostatic activities. We show here that the saliva of ixodid ticks reduces polymorphonuclear leukocyte (PMN) adhesion via downregulation of beta2-integrins and decreases the efficiency of PMN in the uptake and killing of spirochetes. Inhibition of integrin adhesion and signaling reduces anti-inflammatory functions of PMN. These effects may favor the initial survival of spirochetes in vivo.
在莱姆病病原体伯氏疏螺旋体自然感染过程中，螺旋体随含有抗炎和抗止血活性的媒介唾液一同进入宿主体内。我们在此表明，硬蜱唾液通过下调β2整合素降低多形核白细胞（PMN）的黏附，并降低PMN摄取和杀灭螺旋体的效率。整合素黏附和信号传导的抑制会降低PMN的抗炎功能。这些效应可能有利于螺旋体在体内的初始存活。
