Nguyen Baochi, Upadhyaya Arpita, van Oudenaarden Alexander, Brenner Michael P
Department of Mathematics and Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Biophys J. 2004 May;86(5):2740-7. doi: 10.1016/S0006-3495(04)74327-1.
The differential adhesion between cells is believed to be the major driving force behind the formation of tissues. The idea is that an aggregate of cells minimizes the overall adhesive energy between cell surfaces. We demonstrate in a model experimental system that there exist conditions where a slowly growing tissue does not minimize this adhesive energy. A mathematical model demonstrates that the instability of a spherical shape is caused by the competition between elastic and surface energies.
细胞间的差异黏附被认为是组织形成背后的主要驱动力。其观点是,细胞聚集体会使细胞表面之间的总黏附能最小化。我们在一个模型实验系统中证明,存在这样的情况:一个缓慢生长的组织并不会使这种黏附能最小化。一个数学模型表明,球形的不稳定性是由弹性和表面能之间的竞争引起的。