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嗜麦芽窄食单胞菌菌株中smeDEF的调控区域，这些菌株表达不同量的多药外排泵SmeDEF。

Regulatory regions of smeDEF in Stenotrophomonas maltophilia strains expressing different amounts of the multidrug efflux pump SmeDEF.

作者信息

Sanchez Patricia, Alonso Ana, Martinez Jose L

机构信息

Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, Campus Universidad Autónoma de Madrid, Cantoblanco, 28049-Madrid, Spain.

出版信息

Antimicrob Agents Chemother. 2004 Jun;48(6):2274-6. doi: 10.1128/AAC.48.6.2274-2276.2004.

DOI:10.1128/AAC.48.6.2274-2276.2004
PMID:15155232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC415575/
Abstract

The smeT-smeDEF region and the smeT gene, which encodes the smeDEF repressor, are highly polymorphic. Few changes in smeT might be associated with smeDEF overexpression. The results obtained with cellular extracts suggest that mutant SmeT proteins cannot bind to the operator and that other transcription factors besides SmeT are involved in the regulation of smeDEF expression.

摘要

编码smeDEF阻遏物的smeT - smeDEF区域和smeT基因具有高度多态性。smeT的微小变化可能与smeDEF的过表达有关。细胞提取物实验结果表明，突变的SmeT蛋白无法与操纵基因结合，并且除SmeT之外的其他转录因子也参与了smeDEF表达的调控。

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本文引用的文献

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Cloning and characterization of SmeT, a repressor of the Stenotrophomonas maltophilia multidrug efflux pump SmeDEF.嗜麦芽窄食单胞菌多药外排泵SmeDEF的阻遏物SmeT的克隆与特性分析
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Topoisomerase II and IV quinolone resistance-determining regions in Stenotrophomonas maltophilia clinical isolates with different levels of quinolone susceptibility.嗜麦芽窄食单胞菌临床分离株中拓扑异构酶II和IV喹诺酮耐药决定区与不同水平的喹诺酮敏感性
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Expression of multidrug efflux pump SmeDEF by clinical isolates of Stenotrophomonas maltophilia.嗜麦芽窄食单胞菌临床分离株中多药外排泵SmeDEF的表达
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Plasmid location and molecular heterogeneity of the L1 and L2 beta-lactamase genes of Stenotrophomonas maltophilia.嗜麦芽窄食单胞菌L1和L2β-内酰胺酶基因的质粒定位及分子异质性
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Cloning and characterization of SmeDEF, a novel multidrug efflux pump from Stenotrophomonas maltophilia.嗜麦芽窄食单胞菌新型多药外排泵SmeDEF的克隆与特性分析
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Stenotrophomonas maltophilia D457R contains a cluster of genes from gram-positive bacteria involved in antibiotic and heavy metal resistance.嗜麦芽窄食单胞菌D457R含有一组来自革兰氏阳性菌的基因，这些基因与抗生素和重金属抗性有关。
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