用于评估体内抗生素后效应对生物膜感染影响的非侵入性光学成像方法。
Noninvasive optical imaging method to evaluate postantibiotic effects on biofilm infection in vivo.
作者信息
Kadurugamuwa Jagath L, Sin Lin V, Yu Jun, Francis Kevin P, Purchio Tony F, Contag Pamela R
机构信息
Xenogen Corporation, 860 Atlantic Ave., Alameda, CA 94501, USA.
出版信息
Antimicrob Agents Chemother. 2004 Jun;48(6):2283-7. doi: 10.1128/AAC.48.6.2283-2287.2004.
Abstract
Eradication of Staphylococcus aureus biofilms after rifampin treatment was tested in a mouse model of device-related infection by using biophotonic imaging. Following treatment, the bioluminescent signals decreased to undetectable levels, irrespective of the age of the biofilm. After the final treatment, the signals rebounded in a time-dependent manner and reached those for the untreated mice. Readministration of rifampin was unsuccessful in eradicating reestablished infections, with the rifampin MICs for such bacteria being increased and with the bacteria having point mutations in the rpoB gene.
摘要
通过生物光子成像在与装置相关感染的小鼠模型中测试了利福平治疗后金黄色葡萄球菌生物膜的根除情况。治疗后，无论生物膜的形成时间长短，生物发光信号均降至检测不到的水平。在最后一次治疗后，信号以时间依赖性方式反弹，并达到未治疗小鼠的信号水平。再次给予利福平未能根除重新建立的感染，此类细菌的利福平最低抑菌浓度增加，且细菌的rpoB基因存在点突变。
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