Taylor O M, Teasdale J, Cowen P N, McMahon M J, Benson E A
Department of Surgery, General Infirmary, Leeds, UK.
Br J Cancer. 1992 Sep;66(3):503-6. doi: 10.1038/bjc.1992.303.
Recent reports have suggested the presence of oestrogen receptors (ER) in pancreatic carcinoma. Therefore the tumour may be sensitive to hormone manipulation therapy. We examined 23 biopsies of human pancreatic carcinoma tissue for the presence of ER. The tissue was assayed by two methods: Iso-electric focusing (IEF) and ER-ICA an immunocytochemical assay. All biopsies were tested with ER-ICA and ten by IEF. Each biopsy was assessed histologically for tumour content and 20 contained adenocarcinoma. None of the samples of pancreatic carcinoma were positive for ER using the ER-ICA, and none demonstrated the binding peak typical of ER in the IEF assay. These results suggest that in pancreatic carcinoma oestrogen receptor is either absent (or at very low levels), or of a different type to that found in breast and uterine tissue. On theoretical grounds at least, this must raise questions as to the oestrogen sensitivity of pancreatic cancer.
近期报告显示胰腺癌组织中存在雌激素受体（ER）。因此，该肿瘤可能对激素调控疗法敏感。我们检测了23份人胰腺癌组织活检样本中ER的存在情况。采用两种方法对组织进行检测：等电聚焦（IEF）和ER-ICA免疫细胞化学检测法。所有活检样本均用ER-ICA检测，其中10份用IEF检测。对每份活检样本进行组织学评估以确定肿瘤含量，20份含有腺癌。使用ER-ICA检测，胰腺癌样本均未呈ER阳性，且在IEF检测中无一显示出典型的ER结合峰。这些结果表明，胰腺癌中要么不存在雌激素受体（或含量极低），要么其类型与乳腺和子宫组织中的不同。至少从理论上讲，这必然会引发关于胰腺癌雌激素敏感性的问题。
