Baron E M, Bobrysheva I V, Varshaver N B
Genetika. 1992 Jun;28(6):35-40.
The induction of gene mutations and chromosome aberrations by the plasmid pEJ6.6 carrying the activated c-Ha-ras-1 oncogene from human bladder carcinoma was studied in cultured Chinese hamster cells. Both an increase in the frequency of gene mutations to 6-mercaptopurine resistance and of chromosome aberrations was observed after pEJ6.6 treatment as compared to control series (pBR322). Thus the results of experiments carried out show that the pEJ6.6 plasmid possesses a mutagenic activity.
在培养的中国仓鼠细胞中研究了携带人膀胱癌活化c-Ha-ras-1癌基因的质粒pEJ6.6诱导基因突变和染色体畸变的情况。与对照系列（pBR322）相比，pEJ6.6处理后观察到对6-巯基嘌呤抗性的基因突变频率和染色体畸变频率均增加。因此，所进行的实验结果表明pEJ6.6质粒具有诱变活性。
