271例实验室确诊的严重急性呼吸综合征（SARS）病例中SARS冠状病毒特异性抗体的动力学研究
Kinetics of severe acute respiratory syndrome (SARS) coronavirus-specific antibodies in 271 laboratory-confirmed cases of SARS.
作者信息
He Zhongping, Dong Qingming, Zhuang Hui, Song Shujing, Peng Guoai, Luo Guangxiang, Dwyer Dominic E
机构信息
Beijing Ditan Hospital, People's Republic of China.
出版信息
Clin Diagn Lab Immunol. 2004 Jul;11(4):792-4. doi: 10.1128/CDLI.11.4.792-794.2004.
Abstract
The sensitivities and specificities of an immunofluorescence assay and an enzyme immunoassay for detection of antibodies specific for severe acute respiratory syndrome coronavirus (SARS-CoV) were compared for 148 laboratory-confirmed SARS cases. The appearance and persistence of SARS-CoV-specific antibodies were assessed, with immunoglobulin G detected in 59% of samples collected within 14 days and persisting for 60 to 95 days after the onset of illness.
摘要
针对148例实验室确诊的严重急性呼吸综合征冠状病毒（SARS-CoV）病例，比较了免疫荧光测定法和酶免疫测定法检测SARS-CoV特异性抗体的敏感性和特异性。评估了SARS-CoV特异性抗体的出现和持续情况，在发病后14天内采集的样本中，59%检测到免疫球蛋白G，且在发病后60至95天内持续存在。
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