Mönnikes H, Bardhan K D, Stanghellini V, Berghöfer P, Bethke T D, Armstrong D
Department of Medicine, Charité, Freie Universität, DE-13353 Berlin, Germany.
Digestion. 2004;69(4):238-44. doi: 10.1159/000079708. Epub 2004 Jul 12.
BACKGROUND/AIMS: Evaluation of the response of gastroesophageal reflux disease (GERD) symptoms to treatment would be facilitated by a brief, valid, reliable and responsive, self-assessed GERD-sensitive scale. We therefore developed the Reflux Questionnaire (ReQuest). This publication describes the psychometric evaluation and validation of ReQuest.
This second phase of development was based on data from a clinical trial of patients with erosive GERD who received pantoprazole 20 or 40 mg daily for 28 days and completed weekly the long, and daily the short version of ReQuest. The psychometric analyses of ReQuest included internal consistency, test-retest reliability and responsiveness. Construct validity was evaluated by comparison with the Gastrointestinal Symptom Rating Scale (GSRS) and the Psychological General Well-Being (PGWB) scale.
Validation of ReQuest indicated very high internal consistency (Cronbach's alpha = 0.90) and test-retest reliability (intraclass correlation coefficient 0.94 (long-long) and 0.86 (short-short)). This was also the case for the two subscales ReQuest-GI and ReQuest-WSO with Cronbach's alpha coefficients of 0.84 and 0.81. Responsiveness was high with a responsiveness index of >0.8 at day 28. Construct validity was good.
ReQuest is a highly reliable, valid and responsive self-assessment tool for evaluating treatment response in patients with erosive GERD, and can be applied daily.
背景/目的：一份简短、有效、可靠且具有反应性的自我评估胃食管反流病（GERD）敏感量表，将有助于评估GERD症状对治疗的反应。因此，我们开发了反流问卷（ReQuest）。本出版物描述了ReQuest的心理测量学评估和验证。
这一开发的第二阶段基于一项针对糜烂性GERD患者的临床试验数据，这些患者每天接受20或40毫克泮托拉唑治疗28天，并每周完成一次长版本以及每天完成一次短版本的ReQuest。ReQuest的心理测量学分析包括内部一致性、重测信度和反应性。通过与胃肠道症状评定量表（GSRS）和心理总体幸福感（PGWB）量表进行比较来评估结构效度。
ReQuest的验证表明其具有非常高的内部一致性（克朗巴哈系数α = 0.90）和重测信度（组内相关系数，长版本 - 长版本为0.94，短版本 - 短版本为0.86）。ReQuest - GI和ReQuest - WSO这两个子量表的克朗巴哈系数分别为0.84和0.81，情况也是如此。在第28天时反应性较高，反应性指数>0.8。结构效度良好。
ReQuest是一种高度可靠、有效且具有反应性的自我评估工具，可以应用于糜烂性GERD患者的治疗反应评估，并且可以每天使用。
