Bardhan K D, Stanghellini V, Armstrong D, Berghöfer P, Gatz G, Mönnikes H
District General Hospital, Rotherham, UK.
Digestion. 2007;75 Suppl 1:48-54. doi: 10.1159/000101082. Epub 2007 May 4.
Reflux Questionnaire (ReQuest), a newly developed gastro-oesophageal reflux disease-sensitive scale, can be used to reliably evaluate the effect of treatment on gastro-oesophageal reflux disease symptoms.
International validation of this scale, in patients suffering from endoscopy-negative gastro-oesophageal reflux disease.
In this open, multicentre and multinational clinical trial 840 endoscopy-negative gastro-oesophageal reflux disease patients received pantoprazole 20 mg daily for 28 days. The long and short versions of ReQuest were completed both in the pre-treatment and treatment phases. For scale development an item reduction analysis was performed. Internal consistency, test-retest reliability and responsiveness were calculated for psychometric analysis. Construct validity was evaluated by comparison with the Gastrointestinal Symptom Rating Scale and the Psychological General Well-being questionnaire by means of correlation coefficients.
Factor analyses confirmed the content validity of both long and short version of ReQuest. Psychometric calculations proved high internal consistency (Cronbach's alpha: 0.9), test-retest reliability [Intraclass Correlation Coefficient: 0.9 (long vs. long) and 0.8 (short vs. short)], and responsiveness (Responsiveness Index 320.3) of the scale, for which also good construct validity was achieved (correlation coefficient: Gastrointestinal Symptom Rating Scale 0.6; Psychological General Well-being -0.4).
ReQuest proved valid, reliable, and responsive in this multinational clinical trial to evaluate treatment response in endoscopy-negative gastro-oesophageal reflux disease patients.
反流问卷（ReQuest）是一种新开发的对胃食管反流病敏感的量表，可用于可靠地评估治疗对胃食管反流病症状的影响。
在患有内镜检查阴性的胃食管反流病患者中对该量表进行国际验证。
在这项开放性、多中心和跨国的临床试验中，840例内镜检查阴性的胃食管反流病患者每天接受20毫克泮托拉唑治疗，持续28天。在治疗前和治疗阶段均完成了ReQuest的长版和短版问卷。为了量表开发，进行了项目简化分析。计算内部一致性、重测信度和反应性以进行心理测量分析。通过与胃肠道症状评定量表和心理总体幸福感问卷的相关系数比较来评估结构效度。
因子分析证实了ReQuest长版和短版的内容效度。心理测量计算证明该量表具有高内部一致性（克朗巴哈系数：0.9）、重测信度[组内相关系数：0.9（长版对长版）和0.8（短版对短版）]和反应性（反应性指数320.3），其结构效度也良好（相关系数：与胃肠道症状评定量表0.6；与心理总体幸福感 -0.4）。
在这项跨国临床试验中，ReQuest被证明在评估内镜检查阴性的胃食管反流病患者的治疗反应方面有效、可靠且具有反应性。
