慢性疲劳综合征中中性粒细胞凋亡增加。
Increased neutrophil apoptosis in chronic fatigue syndrome.
作者信息
Kennedy G, Spence V, Underwood C, Belch J J F
机构信息
Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
出版信息
J Clin Pathol. 2004 Aug;57(8):891-3. doi: 10.1136/jcp.2003.015511.
Abstract
BACKGROUND/AIMS: Many patients with chronic fatigue syndrome (CFS) have symptoms that are consistent with an underlying viral or toxic illness. Because increased neutrophil apoptosis occurs in patients with infection, this study examined whether this phenomenon also occurs in patients with CFS.
METHODS
Apoptosis was assessed in patients with CFS in conjunction with concentrations of the anti-inflammatory cytokine, transforming growth factor beta1 (TGFbeta1).
RESULTS
The 47 patients with CFS had higher numbers of apoptotic neutrophils, lower numbers of viable neutrophils, increased annexin V binding, and increased expression of the death receptor, tumour necrosis factor receptor-I, on their neutrophils than did the 34 healthy controls. Patients with CFS also had raised concentrations of active TGFbeta1 (p < 0.005).
CONCLUSIONS
These findings provide new evidence that patients with CFS have an underlying detectable abnormality in their immune cells.
摘要
背景/目的：许多慢性疲劳综合征（CFS）患者的症状与潜在的病毒感染或中毒性疾病相符。由于感染患者会出现中性粒细胞凋亡增加的情况，本研究旨在探讨这种现象是否也会在CFS患者中出现。
方法
对CFS患者的凋亡情况进行评估，并检测抗炎细胞因子转化生长因子β1（TGFβ1）的浓度。
结果
47例CFS患者的凋亡中性粒细胞数量较多，存活中性粒细胞数量较少，膜联蛋白V结合增加，且其嗜中性粒细胞上死亡受体肿瘤坏死因子受体-I的表达增加，与34例健康对照相比差异显著。CFS患者的活性TGFβ1浓度也有所升高（p < 0.005）。
结论
这些发现提供了新的证据，表明CFS患者的免疫细胞存在潜在的可检测异常。
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