Clinical Laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, China.
Feiyan Biotechnology Company Limited, Beijing, China.
J Immunol Res. 2020 Apr 2;2020:3232061. doi: 10.1155/2020/3232061. eCollection 2020.
MicroRNAs are a class of conserved, 20 nt-23 nt long, noncoding small RNAs that inhibit expression of their respective target genes in different cell types. Regulatory T cells (Tregs) are a subpopulation of T cells that negatively regulate immune responses, which is essential to immune homeostasis. Recent studies have indicated that microRNAs play an important role in the proliferation, differentiation, and functions of Treg. Here, we review the recent progress in understanding the roles of microRNAs in Treg and their dysregulation in immune-related diseases. This ongoing research continues to expand the understanding of Treg regulation and the mechanisms of immune disorders.
MicroRNAs 是一类保守的、20nt-23nt 长的非编码小 RNA，能够在不同的细胞类型中抑制其各自靶基因的表达。调节性 T 细胞（Treg）是 T 细胞的一个亚群，它们负向调节免疫反应，这对于免疫稳态至关重要。最近的研究表明，microRNAs 在 Treg 的增殖、分化和功能中发挥着重要作用。在这里，我们综述了 microRNAs 在 Treg 中的作用及其在免疫相关疾病中的失调的最新研究进展。这一持续的研究不断拓展了对 Treg 调控和免疫紊乱机制的理解。
