Yang Dong-Yun, Li Shi-Rong, Li Gang, Liu Jian-Yi, Wang Zhen-Xiang, Wu Ju-Long, Chen Yan-Qing
Department of Plastic Surgery, Southwest Hospital, The Third Military Medical University, Chongqing 400038, P. R. China.
Zhonghua Shao Shang Za Zhi. 2004 Apr;20(2):82-4.
To establish an ideal model of human hyperplastic scar (HS) in nude mice, so as to provide us a new model to carry out further studies on the mechanism of HS development.
Full skin defect sized 2.0 cm x 1.5 cm was created on the back of 100 nude mice. The defect was thereafter covered with full thickness human skin. After the grafted skin survived, the nude mice were subjected to deep partial thickness burn of the grafted skin with heated copper rod. The development of the hyperplasia of the scar after wound healing was observed histologically and grossly.
Grafted full-thickness human skin took and survived well in 86 out of 100 nude mice. There was obvious and continuous hyperplasia of scar in 67 mice (78%). The external appearance and histological features of the HS appeared similar to those in human HS. The average thickness of the scar was 0.34 cm, with the thickest part measuring 0.6 cm. In addition, the time of hyperplastic change lasted for 63 - 217 days in average of 128 days.
Obvious and continuous scar hyperplasia could be found in this model, and the whole process beginning from wound healing to the formation of HS could be easily observed. The model was therefore suitable and ideal for the study of HS.
在裸鼠中建立理想的人增生性瘢痕（HS）模型，为进一步研究HS发生机制提供新的模型。
在100只裸鼠背部制造大小为2.0 cm×1.5 cm的全层皮肤缺损。缺损处随后覆盖全层人皮肤。移植皮肤存活后，用加热的铜棒对移植皮肤进行深Ⅱ度烧伤。在伤口愈合后观察瘢痕增生的发展情况，进行大体和组织学观察。
100只裸鼠中有86只移植的全层人皮肤成活良好。67只小鼠（78%）出现明显且持续的瘢痕增生。HS的外观和组织学特征与人HS相似。瘢痕平均厚度为0.34 cm，最厚处为0.6 cm。此外，增生性变化的时间平均持续63 - 217天，平均为128天。
该模型可出现明显且持续的瘢痕增生，易于观察从伤口愈合到HS形成的全过程。因此该模型适合且理想用于HS的研究。
