Xiang Jun, Wang Zhi-yong, Jia Sheng-xian, Jin Shu-wen, Lu Shu-liang, Liao Zhen-jiang
Department of Burns, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, P.R. China.
Zhonghua Shao Shang Za Zhi. 2004 Oct;20(5):281-3.
To establish an animal model of hypertrophic scar on the rabbit ears and to observe the dynamic process of scar formation on the ventral side of the rabbit ears.
Full skin defect (2 cm x 5 cm in diameter) was created on the ventral side of 60 ears in 32 New Zealand white rabbits. 1% silver sulfadiazine cream was applied to the wounds, and the dressing was changed once a week till wound healing. Four ears without operation were taken as control. Wound healing under natural condition was observed continuously for 12 months after the operation. The scar proliferation on the rabbit ears was observed by light microscope and transmission electron microscope, and the scar index was determined by computer image analyzing system.
The color, thickness and texture of the wounds on the rabbit ears after epithelization underwent a process of scar overgrowth, maturation and degeneration. The change in scar index was in accordance with the wax and wane of scar proliferation.
The hypertrophic scar formed on the ventral side of rabbit ears after natural healing of full thickness skin wounds was similar to that in humans. The results indicated that this animal model was ideal for the study of the developmental mechanism of hypertrophic scars and for the evaluation of the efficacy of the prevention and treatment of hypertrophic scars.
建立兔耳增生性瘢痕动物模型，观察兔耳腹侧瘢痕形成的动态过程。
对32只新西兰白兔的60只耳朵腹侧造成全层皮肤缺损（直径2 cm×5 cm）。创面涂抹1%磺胺嘧啶银乳膏，每周换药1次直至创面愈合。取4只未手术的耳朵作为对照。术后连续12个月观察创面在自然条件下的愈合情况。通过光学显微镜和透射电子显微镜观察兔耳瘢痕增生情况，并用计算机图像分析系统测定瘢痕指数。
上皮化后兔耳创面的颜色、厚度和质地经历了瘢痕过度生长、成熟和退变的过程。瘢痕指数的变化与瘢痕增生的消长一致。
全层皮肤创面自然愈合后兔耳腹侧形成的增生性瘢痕与人的相似。结果表明，该动物模型是研究增生性瘢痕发生机制及评估增生性瘢痕防治效果的理想模型。
