Miles Michael V, Horn Paul S, Tang Peter H, Morrison John A, Miles Lili, DeGrauw Ton, Pesce Amadeo J
Divisions of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.
Clin Chim Acta. 2004 Sep;347(1-2):139-44. doi: 10.1016/j.cccn.2004.04.003.
Coenzyme Q10 (CoQ) is an endogenous enzyme cofactor, which may provide protective benefits as an antioxidant. Because age-related CoQ changes and deficiency states have been described, there is a need to establish normal ranges in healthy children. The objectives of this study are to determine if age-related differences in reduced CoQ (ubiquinol), oxidized CoQ (ubiquinone), and CoQ redox state exist in childhood, and to establish reference intervals for these analytes in healthy children.
Apparently healthy children (n=68) were selected from individuals with no history of current acute illness, medically diagnosed disease, or current medication treatment. Self-reported healthy adults (n=106) were selected from the ongoing Princeton Follow-up Study in greater Cincinnati. Participants were assessed for lipid profiles, ubiquinol concentration, ubiquinone concentration, total CoQ concentration, and CoQ redox ratio.
Mean total CoQ and ubiquinol concentrations are similar in younger children (0.2-7.6 years) and adults (29-78 years); however, lipid-adjusted total CoQ concentrations are significantly increased in younger children. Also CoQ redox ratio is significantly increased in younger and older children compared with adults.
Elevated CoQ and redox ratios in children may be an indication of oxidative stress effects, which are associated with early development of coronary heart disease.
辅酶Q10（CoQ）是一种内源性酶辅因子，作为抗氧化剂可能具有保护作用。由于已描述了与年龄相关的CoQ变化和缺乏状态，因此有必要确定健康儿童的正常范围。本研究的目的是确定儿童期还原型CoQ（泛醇）、氧化型CoQ（泛醌）和CoQ氧化还原状态是否存在与年龄相关的差异，并建立健康儿童这些分析物的参考区间。
从无当前急性疾病、医学诊断疾病或当前药物治疗史的个体中选取表面健康的儿童（n = 68）。自我报告健康的成年人（n = 106）选自正在进行的大辛辛那提地区普林斯顿随访研究。对参与者进行血脂谱、泛醇浓度、泛醌浓度、总CoQ浓度和CoQ氧化还原比的评估。
年幼儿童（0.2 - 7.6岁）和成年人（29 - 78岁）的平均总CoQ和泛醇浓度相似；然而，年幼儿童经脂质调整后的总CoQ浓度显著升高。此外，与成年人相比，年幼儿童和年长儿童的CoQ氧化还原比均显著升高。
儿童中CoQ和氧化还原比升高可能表明存在氧化应激效应，这与冠心病的早期发展有关。
