Mochi M, Sangiorgi S, Cortelli P, Carelli V, Scapoli C, Crisci M, Monari L, Pierangeli G, Montagna P
Istituto di Clinica Neurologica, Università di Bologna, Italy.
Cephalalgia. 1993 Dec;13(6):389-94. doi: 10.1046/j.1468-2982.1993.1306389.x.
We collected two clinically matched samples of patients, one sample affected by migraine with aura the other by migraine without aura, to investigate the genetic determination of these conditions. A maternal and X-linked transmission for both these diseases was considered unlikely after pedigree analysis. Classical segregation analysis indicated a likely autosomal recessive kind of transmission for both. Reduced penetrance and the h2 values, however, imply the presence of additional genetic and/or environmental factors controlling the phenotypic expression of migraine.
我们收集了两组临床匹配的患者样本，一组患有先兆偏头痛，另一组患有无先兆偏头痛，以研究这些病症的遗传决定因素。系谱分析后认为这两种疾病不太可能是母系和X连锁遗传。经典分离分析表明这两种疾病可能都是常染色体隐性遗传。然而，较低的外显率和h2值表明存在其他控制偏头痛表型表达的遗传和/或环境因素。
